Structure of PDB 7pf2 Chain G Binding Site BS02

Receptor Information

>7pf2 Chain G (length=109) Species: 9606 (Homo sapiens)

ARAKAKTRSSRAGLQFPVGRVHRLLRKGNYSERVGAGAPVYLAAVLEYLT
AEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLP
NIQAVLLPK

Ligand information

>7pf2 Chain J (length=339)

tacttacatgacaggatgtatatatctgacacgtgcctggagactaggga
gtaatccccttggcggttaaaacgcgggggacagcgcgtacgtgcgttta
agcggtgctagagctgtctacgaccaattgagcggcctcggcaccgggat
tctccaggcggccagtgcgcgatacttacatgacaggatgtatatatctg
acacgtgcctggagactagggagtaatccccttggcggttaaaacgcggg
ggacagcgcgtacgtgcgtttaagcggtgctagagctgtctacgaccaat
tgagcggcctcggcaccgggattctccaggcggccagtg

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7pf2 Histone H1 binding to nucleosome arrays depends on linker DNA length and trajectory.
• Resolution: 5.1 Å
• Binding residue (original residue number in PDB): K15 T16 R17 R20 G28 R29 R32 R42 R77
• Binding residue (residue number reindexed from 1): K6 T7 R8 R11 G19 R20 R23 R33 R68

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0005515 protein binding
• GO:0030527 structural constituent of chromatin
• GO:0031492 nucleosomal DNA binding
• GO:0046982 protein heterodimerization activity

Biological Process

• GO:0006325 chromatin organization
• GO:0008285 negative regulation of cell population proliferation
• GO:0031507 heterochromatin formation
• GO:0061644 protein localization to CENP-A containing chromatin

Cellular Component

• GO:0000786 nucleosome
• GO:0005634 nucleus
• GO:0005694 chromosome
• GO:0043505 CENP-A containing nucleosome
• GO:0070062 extracellular exosome

External links

• PDB: RCSB:7pf2, PDBe:7pf2, PDBj:7pf2
• PDBsum: 7pf2
• PubMed: 35581345
• UniProt: P04908|H2A1B_HUMAN Histone H2A type 1-B/E (Gene Name=H2AC4)