Structure of PDB 7p7k Chain G Binding Site BS02

Receptor Information
>7p7k Chain G (length=905) Species: 469008 (Escherichia coli BL21(DE3)) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ATIHVDGKEYEVNGADNLLEACLSLGLDIPYFCWHPALGSVGACRQCAVK
QYQNAEDTRGRLVMSCMTPASDGTFISIDDEEAKQFRESVVEWLMTNHPH
DCPVCEEGGNCHLQDMTVMTGHSFRRYRFTKRTHRNQDLGPFISHEMNRC
IACYRCVRYYKDYAGGTDLGVYGAHDNVYFGRPEDGTLESEFSGNLVEIC
PTGVFTDKTHSERYNRKWDMQFAPSICQQCSIGCNISPGERYGELRRIEN
RYNGTVNHYFLCDRGRFGYGYVNLKDRPRQPVQRRGDDFITLNAEQAMQG
AADILRQSKKVIGIGSPRASVESNFALRELVGEENFYTGIAHGEQERLQL
ALKVLREGGIYTPALREIESYDAVLVLGEDVTQTGARVALAVRQAVKGKA
REMAAAQKVADWQIAAILNIGQRAKHPLFVTNVDDTRLDDIAAWTYRAPV
EDQARLGFAIAHALDNSAPAVDGIEPELQSKIDVIVQALAGAKKPLIISG
TNAGSLEVIQAAANVAKALKGRGADVGITMIARSVNSMGLGIMGGGSLEE
ALTELETGRADAVVVLENDLHRHASATRVNAALAKAPLVMVVDHQRTAIM
ENAHLVLSAASFAESDGTVINNEGRAQRFFQVYDPAYYDSKTVMLESWRW
LHSLHSTLLSREVDWTQLDHVIDAVVAKIPELAGIKDAAPDATFRIRGQK
LAREPHRYSGRTAMRANISVHEPRQPQDIDTMFTFSMEGNNQPTAHRSQV
PFAWAPGWNSPQAWNKFQDEVGGKLRFGDPGVRLFETSENGLDYFTSVPA
RFQPQDGKWRIAPYYHLFGSDELSQRAPVFQSRMPQPYIKLNPADAAKLG
VNAGTRVSFSYDGNTVTLPVEIAEGLTAGQVGLPMGMSGIAPVLAGAHLE
DLKEA
Ligand information
Ligand IDSF4
InChIInChI=1S/4Fe.4S
InChIKeyLJBDFODJNLIPKO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7[S]12[Fe]3[S]4[Fe]1[S]5[Fe]2[S]3[Fe]45
CACTVS 3.385S1[Fe]S[Fe]1.S2[Fe]S[Fe]2
FormulaFe4 S4
NameIRON/SULFUR CLUSTER
ChEMBL
DrugBank
ZINC
PDB chain7p7k Chain G Residue 1002 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7p7k A universal coupling mechanism of respiratory complex I.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		C153 I154 A155 C156 Y157 R158 C159 F183 C203 P204 V207
Binding residue
(residue number reindexed from 1)		C150 I151 A152 C153 Y154 R155 C156 F180 C200 P201 V204
Annotation score1
Enzymatic activity
Enzyme Commision number 7.1.1.-
Gene Ontology
Molecular Function
GO:0003954 NADH dehydrogenase activity
GO:0005515 protein binding
GO:0008137 NADH dehydrogenase (ubiquinone) activity
GO:0010181 FMN binding
GO:0016491 oxidoreductase activity
GO:0016651 oxidoreductase activity, acting on NAD(P)H
GO:0043546 molybdopterin cofactor binding
GO:0046872 metal ion binding
GO:0048038 quinone binding
GO:0051536 iron-sulfur cluster binding
GO:0051537 2 iron, 2 sulfur cluster binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0009060 aerobic respiration
GO:0022904 respiratory electron transport chain
GO:0042773 ATP synthesis coupled electron transport
GO:0045333 cellular respiration
GO:1902600 proton transmembrane transport
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030964 NADH dehydrogenase complex
GO:0045271 respiratory chain complex I
GO:1990204 oxidoreductase complex

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7p7k, PDBe:7p7k, PDBj:7p7k
PDBsum7p7k
PubMed36104567
UniProtP33602|NUOG_ECOLI NADH-quinone oxidoreductase subunit G (Gene Name=nuoG)

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