Structure of PDB 7mj5 Chain G Binding Site BS02

Receptor Information
>7mj5 Chain G (length=257) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTA
NVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDA
CEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWI
QKVIDQF
Ligand information
>7mj5 Chain P (length=29) Species: 163159 (Xenopsylla cheopis) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
EVAQPKLYQRGEGGNGMEPIPEDVLNEAL
Receptor-Ligand Complex Structure
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PDB7mj5 Identification of a substrate-like cleavage-resistant thrombin inhibitor from the saliva of the flea Xenopsylla cheopis.
Resolution2.15 Å
Binding residue
(original residue number in PDB)		F34 Q38 E39 L40 H57 Y60A W60D R73 T74 Y76 I82 E97A N98 N143 Q151 R173 I174 A190 C191 E192 G193 S195 S214 W215 G216
Binding residue
(residue number reindexed from 1)		F19 Q24 E25 L26 H43 Y47 W50 R68 T69 Y71 I78 E94 N95 N143 Q156 R178 I179 A200 C201 E202 G203 S205 S226 W227 G228
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:7mj5, PDBe:7mj5, PDBj:7mj5
PDBsum7mj5
PubMed34688666
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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