Structure of PDB 6t93 Chain G Binding Site BS02

Receptor Information

>6t93 Chain G (length=108) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

RAKAKTRSSRAGLQFPVGRVHRLLRKGNYSERVGAGAPVYLAAVLEYLTA
EILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPN
IQAVLLPK

Ligand information

>6t93 Chain J (length=151) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

tcacaggatgtatatatctgacacgtgcctggagactagggagtaatccc
cttggcggttaaaacgcgggggacagcgcgtacgtgcgtttaagcggtgc
tagagctgtctacgaccaattgagcggatttgcataacaaagtctccagg
a

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6t93 Mechanisms of OCT4-SOX2 motif readout on nucleosomes.
Resolution	3.49 Å
Binding residue (original residue number in PDB)	R12 A13 K16 R18 R78
Binding residue (residue number reindexed from 1)	R1 A2 K5 R7 R67

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0030527	structural constituent of chromatin
GO:0031492	nucleosomal DNA binding
GO:0046982	protein heterodimerization activity

	Biological Process
GO:0006325	chromatin organization
GO:0008285	negative regulation of cell population proliferation
GO:0031507	heterochromatin formation
GO:0061644	protein localization to CENP-A containing chromatin

	Cellular Component
GO:0000786	nucleosome
GO:0005634	nucleus
GO:0005694	chromosome
GO:0043505	CENP-A containing nucleosome
GO:0070062	extracellular exosome

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Cellular Component

External links

PDB	RCSB:6t93, PDBe:6t93, PDBj:6t93
PDBsum	6t93
PubMed	32327602
UniProt	P04908\|H2A1B_HUMAN Histone H2A type 1-B/E (Gene Name=H2AC4)

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