Structure of PDB 6rme Chain G Binding Site BS02

Receptor Information

>6rme Chain G (length=372) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

WNSRYSYNQLKNKDSLIMFLVEIFRSLFVSNCIDKNIDNVLLSIEEMFID
HYYNPQHSRLKYLIDDVGIFFTKLPITKAFHTYNKKYRITKRLYAPPTFN
EVRHILNLAQILSLEEGLDLLTFDANETLYPDGHDFNDEVLASYISCLLK
KMNIAIVTAASYNNDAEKYQKRLENLLKYFSKHNIKDGSYKNFYVMGGES
NYLFKCNEEATLYSVPENEWRHYKKFVDYDTVQEILNISEKCLEKVIKDF
GLCAQIQRKEKSIGLVPNKIMIKYEVLEEAVIRIKKEIIKNKITAPYCAF
NGGQDLWVDVGNKAEGLLILQKLLKIQKKKCCHIGDQFLHSGNDFPTRFC
SLTLWVSNPQETKACLKSIMHL

Ligand information

Ligand ID

InChI

InChI=1S/Mg/q+2

InChIKey

JLVVSXFLKOJNIY-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Mg+2]
CACTVS 3.341	[Mg++]

Formula

Name

MAGNESIUM ION

PDB chain

6rme Chain G Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

Global view

Local view

Structure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

PDB	6rme Structure and catalytic regulation of Plasmodium falciparum IMP specific nucleotidase.
Resolution	3.4 Å
Binding residue (original residue number in PDB)	D170 D394 Q395
Binding residue (residue number reindexed from 1)	D124 D336 Q337
Annotation score	1

Enzymatic activity

Enzyme Commision number

3.1.3.99: IMP-specific 5'-nucleotidase.

Gene Ontology

	Molecular Function
GO:0000287	magnesium ion binding
GO:0050483	IMP 5'-nucleotidase activity

	Biological Process
GO:0006190	inosine salvage
GO:0009117	nucleotide metabolic process

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:6rme, PDBe:6rme, PDBj:6rme
PDBsum	6rme
PubMed	32591529
UniProt	A0A144A134\|ISN1_PLAF7 IMP-specific 5'-nucleotidase 1 (Gene Name=ISN1)

[Back to BioLiP]