Structure of PDB 6n1p Chain G Binding Site BS02

Receptor Information

>6n1p Chain G (length=476) Species: 512566 (Streptococcus pneumoniae G54) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

LTKEMKASFIDYAMSVIVARALPDVRDGLKPVHRRILYGMNELGVTPDKP
HKKSARITGDVMGKYHPHGDSSIYEAMVRMAQWWSYRYMLVDGHGNFGSM
DGDSAAAQRYTEARMSKIALEMLRDINKNTVDFVDNYDANEREPLVLPAR
FPNLLVNGATGIAVGMATNIPPHNLGETIDAVKLVMDNPEVTTKDLMEVL
PGPDFPTGALVMGKSGIHKAYETGKGSIVLRSRTEIETTKTGRERIVVTE
FPYMVNKTKVHEHIVRLVQEKRIEGITAVRDESNREGVRFVIEVKRDASA
NVILNNLFKMTQMQTNFGFNMLAIQNGIPKILSLRQILDAYIEHQKEVVV
RRTRFDKEKAEARAHILEGLLIALDHIDEVIRIIRASETDAEAQAELMSK
FKLSERQSQAILDMRLRRLTGLERDKIQSEYDDLLALIADLADILAKPER
VSQIIKDELDEVKRKFSDKRRTELMV

Ligand information

>6n1p Chain J (length=44) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

tcgcgacgcgaggctggatggccttccccattatgattcttctc

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6n1p CryoEM structures of open dimers of Gyrase A in complex with DNA illuminate mechanism of strand passage.
Resolution	6.35 Å
Binding residue (original residue number in PDB)	K436 S439
Binding residue (residue number reindexed from 1)	K426 S429

Enzymatic activity

Enzyme Commision number

5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003918	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524	ATP binding

	Biological Process
GO:0006259	DNA metabolic process
GO:0006265	DNA topological change

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Molecular Function

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Biological Process

External links

PDB	RCSB:6n1p, PDBe:6n1p, PDBj:6n1p
PDBsum	6n1p
PubMed	30457554
UniProt	Q8DPM2\|GYRA_STRR6 DNA gyrase subunit A (Gene Name=gyrA)

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