Structure of PDB 5zoo Chain G Binding Site BS02

Receptor Information
>5zoo Chain G (length=387) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FTTGLVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECI
RGRKATLEELQTVHSEAHTLLYGTNPLSVFVRLPCGGVGVDSDTIWNEVH
SAGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFN
SVAVAAKLLQQRLSVSKILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYD
DGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAFRTVVM
PIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQLMGLAGG
RIVLALEGGYDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRS
MEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEA
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5zoo Chain G Residue 1103 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5zoo Structural basis of the specific interaction of SMRT corepressor with histone deacetylase 4.
Resolution1.85 Å
Binding residue
(original residue number in PDB)		D840 H842 D934
Binding residue
(residue number reindexed from 1)		D174 H176 D268
Annotation score1
Enzymatic activity
Enzyme Commision number 3.5.1.98: histone deacetylase.
External links
PDB RCSB:5zoo, PDBe:5zoo, PDBj:5zoo
PDBsum5zoo
PubMed30321390
UniProtP56524|HDAC4_HUMAN Histone deacetylase 4 (Gene Name=HDAC4)

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