Structure of PDB 5nrl Chain G Binding Site BS02

Receptor Information
>5nrl Chain G (length=372) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EKFQGHGLKTELHSALKSSNLNLIRRTYQTGENPYLSNRRYERGLKFKRI
AQERTLQKQQEEEELKRKLKQEEDEKDKRKLIESGDPNLELHEDKFLLDL
SKFKIYYDNNHGYEWWDTAYHPSIRYVAHPLPEKAKVSIKAYLTQHERKR
LRRNRRKMAREAREIKIKLGLLPKPEPKVKLSNMMSVFENDQNITDPTAW
EKVVKDQVDLRKRKHLEENERRHEDAIKRRKEAVNMNVEKPTVYHCKVFQ
FKNLQNPKIRFKLKMNSKELSLKGLCLRIRDDGPGIIIVVGNEKSCKFYE
NLVMKRIKWNEDFELHTGDIKMDMHNNSISKTWEGYLQDCKFKGWFMKVC
NDQDSLLRTLGQFDSEHFYSPV
Ligand information
>5nrl Chain 6 (length=95) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
guucgcgaacuucguggacauuuggucaauuugaaacaauacagagauca
gcaguuccccugcauaaggaugaaccguucaaagagauuuguuuu
Receptor-Ligand Complex Structure
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PDB5nrl Structure of a pre-catalytic spliceosome.
Resolution7.2 Å
Binding residue
(original residue number in PDB)		R253 K271 N276 S279 E282 N312 H316 A319 R323 P350 K351 R353 F354 K357 M358 E362 R371 K387 N394 R399 F441 M442 K443 Q457
Binding residue
(residue number reindexed from 1)		R160 K178 N183 S186 E189 N219 H223 A226 R230 P257 K258 R260 F261 K264 M265 E269 R278 K294 N301 R306 F346 M347 K348 Q362
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0000245 spliceosomal complex assembly
GO:0000387 spliceosomal snRNP assembly
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
Cellular Component
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0005687 U4 snRNP
GO:0046540 U4/U6 x U5 tri-snRNP complex
GO:0071001 U4/U6 snRNP

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5nrl, PDBe:5nrl, PDBj:5nrl
PDBsum5nrl
PubMed28530653
UniProtQ03338|PRP3_YEAST U4/U6 small nuclear ribonucleoprotein PRP3 (Gene Name=PRP3)

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