Structure of PDB 5gm6 Chain G Binding Site BS02

Receptor Information
>5gm6 Chain G (length=875) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SHQLGGQYSIPQDLRENLQKEAARIGENEKDVLQEKMETRTVQNREDSYH
KRRFDMKFELNKDEKKERTLSMLLLKIKNGNTASRRTSMRILTDKAVTFG
PEMIFNRLLPILLDRSLEDQERHLMIKTIDRVLYQLGDLTKPYVHKILVV
AAPLLIDEDPMVRSTGQEIITNLSTVAGLKTILTVMRPDIENEDEYVRNV
TSRAAAVVAKALGVNQLLPFINAACHSRKSWKARHTGIKIVQQIGILLGI
GVLNHLTGLMSCIKDCLMDDHVPVRIVTAHTLSTLAENSYPYGIEVFNVV
LEPLWKGIRSHRGKVLSSFLKAVGSMIPLMDPEYAGYYTTEAMRIIRREF
DSPDDEMKKTILLVLQKCSAVESITPKFLREEIAPEFFQKFWVRRVALDR
PLNKVVTYTTVTLAKKLGCSYTIDKLLTPLRDEAEPFRTMAVHAVTRTVN
LLGTADLDERLETRLIDALLIAFQEQTNSDSIIFKGFGAVTVSLDIRMKP
FLAPIVSTILNHLKHKTPLVRQHAADLCAILIPVIKNCHEFEMLNKLNII
LYESLGEVYPEVLGSIINAMYCITSVMDLDKLQPPINQILPTLTPILRNK
HRKVEVNTIKFVGLIGKLAPTYAPPKEWMRICFELLELLKSTNKEIRRSA
NATFGFIAEAIGPHDVLVALLNNLKVQERQLRVCTAVAIGIVAKVCGPYN
VLPVIMNEYTTPETNVQNGVLKAMSFMFEYIGNMSKDYIYFITPLLEDAL
TDRDLVHRQTASNVITHLALNCSGTGHEDAFIHLMNLLIPNIFETSPHAI
MRILEGLEALSQALGPGLFMNYIWAGLFHPAKNVRKAFWRVYNNMYVMYQ
DAMVPFYPVTPDNNEEYIEELDLVL
Ligand information
>5gm6 Chain M (length=50) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
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..................................................
Receptor-Ligand Complex Structure
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PDB5gm6 Structure of a yeast activated spliceosome at 3.5 angstrom resolution
Resolution3.5 Å
Binding residue
(original residue number in PDB)		Y64 H65 I252 E254 R259 E291 N295 R299 I342 V368 R408 P449 N499 K500 T503 Y504 H539 R543 R698 T738 K740 R744 N747 R775 R778 V783 K818 H894 R898
Binding residue
(residue number reindexed from 1)		Y49 H50 I156 E158 R163 E195 N199 R203 I246 V272 R312 P353 N403 K404 T407 Y408 H443 R447 R602 T642 K644 R648 N651 R679 R682 V687 K722 H798 R802
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003729 mRNA binding
GO:0005515 protein binding
Biological Process
GO:0000245 spliceosomal complex assembly
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:1903241 U2-type prespliceosome assembly
Cellular Component
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0005684 U2-type spliceosomal complex
GO:0005686 U2 snRNP
GO:0071004 U2-type prespliceosome
GO:0071013 catalytic step 2 spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5gm6, PDBe:5gm6, PDBj:5gm6
PDBsum5gm6
PubMed27445306
UniProtP49955|SF3B1_YEAST U2 snRNP component HSH155 (Gene Name=HSH155)

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