Structure of PDB 4pkg Chain G Binding Site BS02

Receptor Information
>4pkg Chain G (length=168) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MVVEHPEFLKAGKEPGLQIWRVEKFDLVPVPTNLYGDFFTGDAYVILKTV
QLRNGNLQYDLHYWLGNECSQDESGAAAIFTVQLDDYLNGRAVQHREVQG
FESATFLGYFKSGLKYKKGGVASGFGPTGPFKREELLDHLEKQAKEFKDR
EDLVPYTGEKRGKVWVPK
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain4pkg Chain G Residue 1201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB4pkg Actin cytoskeleton. Mechanism of actin filament pointed-end capping by tropomodulin.
Resolution1.8 Å
Binding residue
(original residue number in PDB)		G92 D93 E124 V172
Binding residue
(residue number reindexed from 1)		G41 D42 E73 V121
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005523 tropomyosin binding
GO:0051015 actin filament binding
Biological Process
GO:0051694 pointed-end actin filament capping

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4pkg, PDBe:4pkg, PDBj:4pkg
PDBsum4pkg
PubMed25061212
UniProtP06396|GELS_HUMAN Gelsolin (Gene Name=GSN);
P28289

[Back to BioLiP]