Structure of PDB 4e7r Chain G Binding Site BS02

Receptor Information
>4e7r Chain G (length=250) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETGQP
SVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGG
PFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4e7r New 3-amidinophenylalanine-derived inhibitors of matriptase
Resolution2.25 Å
Binding residue
(original residue number in PDB)		F1034 Q1038 L1065 R1067 R1073 T1074 Y1076 K1081 I1082
Binding residue
(residue number reindexed from 1)		F19 Q24 L60 R62 R68 T69 Y71 K77 I78
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:4e7r, PDBe:4e7r, PDBj:4e7r
PDBsum4e7r
PubMed
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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