Structure of PDB 3i3t Chain G Binding Site BS02

Receptor Information
>3i3t Chain G (length=304) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVQELTEAFADVI
GALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLE
INRRLSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQACGYRSTTF
EVFCDLSLPIPKKVSLRDCFNLFTKEEELESENAPVCDRCRQKTRSTKKL
TVQRFPRILVLHLNRFSASRGSIKKSSVGVDFPLQRLSLGDFASSPVYQL
YALCNHSGSVHYGHYTALCRCQTGWHVYNDSRVSPVSENQVASSEGYVLF
YQLM
Ligand information
Ligand IDNEH
InChIInChI=1S/C2H7N/c1-2-3/h2-3H2,1H3
InChIKeyQUSNBJAOOMFDIB-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341
OpenEye OEToolkits 1.5.0		CCN
ACDLabs 10.04NCC
FormulaC2 H7 N
NameETHANAMINE
ChEMBLCHEMBL14449
DrugBank
ZINC
PDB chain3i3t Chain H Residue 76 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3i3t A strategy for modulation of enzymes in the ubiquitin system.
Resolution2.59 Å
Binding residue
(original residue number in PDB)		N219 C221
Binding residue
(residue number reindexed from 1)		N9 C11
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) H518 N533
Catalytic site (residue number reindexed from 1) H264 N279
Enzyme Commision number 3.4.19.12: ubiquitinyl hydrolase 1.
Gene Ontology
Molecular Function
GO:0004843 cysteine-type deubiquitinase activity
Biological Process
GO:0016579 protein deubiquitination

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:3i3t, PDBe:3i3t, PDBj:3i3t
PDBsum3i3t
PubMed23287719
UniProtQ9UK80|UBP21_HUMAN Ubiquitin carboxyl-terminal hydrolase 21 (Gene Name=USP21)

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