Structure of PDB 2pf4 Chain G Binding Site BS02

Receptor Information
>2pf4 Chain G (length=142) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MDKVLNREESLQLMDLLGLERSAWGNIPLMRKAYLKKCKEFKMKKMNTLY
KKMEDGVKYAHVDAIYCKQWPECVKKMSTNCICLLCLLRMKHENRKLYRK
DPLVWVDCYCFDCFRMWFGLDLCEGTLLLWCDIIGQTTYRDL
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain2pf4 Chain G Residue 802 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB2pf4 Structural basis of PP2A inhibition by small t antigen.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		H122 C138 C140 C143
Binding residue
(residue number reindexed from 1)		H92 C108 C110 C113
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0039657 symbiont-mediated suppression of host gene expression
Cellular Component
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:2pf4, PDBe:2pf4, PDBj:2pf4
PDBsum2pf4
PubMed17608567
UniProtP03081|ST_SV40 Small t antigen

[Back to BioLiP]