Structure of PDB 2j4e Chain G Binding Site BS02
Receptor Information
>2j4e Chain G (length=186) Species:
9606
(Homo sapiens) [
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SMAASLVGKKIVFVTGNAKKLEEVVQILGDKFPCTLVAQKIDLPEYQGEP
DEISIQKCQEAVRQVQGPVLVEDTCLCFNALGGLPGPYIKWFLEKLKPEG
LHQLLAGFEDKSAYALCTFALSTPVRLFRGRTSGRIVAPRGCQDFGWDPC
FQPDGYEQTYAEMPKAEKNAVSHRFRALLELQEYFG
Ligand information
Ligand ID
MG
InChI
InChI=1S/Mg/q+2
InChIKey
JLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
Software
SMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0
[Mg+2]
CACTVS 3.341
[Mg++]
Formula
Mg
Name
MAGNESIUM ION
ChEMBL
DrugBank
DB01378
ZINC
PDB chain
2j4e Chain G Residue 1002 [
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Receptor-Ligand Complex Structure
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PDB
2j4e
Crystal Structure of Human Inosine Triphosphatase: Substrate Binding and Implication of the Inosine Triphosphatase Deficiency Mutation P32T.
Resolution
2.8 Å
Binding residue
(original residue number in PDB)
E44 K89
Binding residue
(residue number reindexed from 1)
E45 K90
Annotation score
1
Enzymatic activity
Enzyme Commision number
3.6.1.9
: nucleotide diphosphatase.
Gene Ontology
Molecular Function
GO:0000166
nucleotide binding
GO:0016787
hydrolase activity
GO:0035870
dITP diphosphatase activity
GO:0036220
ITP diphosphatase activity
GO:0036222
XTP diphosphatase activity
GO:0042802
identical protein binding
GO:0046872
metal ion binding
GO:0047429
nucleoside triphosphate diphosphatase activity
Biological Process
GO:0006193
ITP catabolic process
GO:0009117
nucleotide metabolic process
GO:0009143
nucleoside triphosphate catabolic process
GO:0009204
deoxyribonucleoside triphosphate catabolic process
GO:0051276
chromosome organization
Cellular Component
GO:0005654
nucleoplasm
GO:0005737
cytoplasm
GO:0005829
cytosol
GO:0043231
intracellular membrane-bounded organelle
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Molecular Function
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Biological Process
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Cellular Component
External links
PDB
RCSB:2j4e
,
PDBe:2j4e
,
PDBj:2j4e
PDBsum
2j4e
PubMed
17138556
UniProt
Q9BY32
|ITPA_HUMAN Inosine triphosphate pyrophosphatase (Gene Name=ITPA)
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