Structure of PDB 1z7m Chain G Binding Site BS02

Receptor Information
>1z7m Chain G (length=203) Species: 1358 (Lactococcus lactis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MIKIAITKGRIQKQVTKLLENADYDVEPILRELQIKTKDDLQIIFGKPND
VITFLEHGIVDIGFVGKDTLDENDFDDYYELLYLKIGQCIFALASYPDFS
NKNFQRHKRIASKYPRVTKKYFAQKQEDIEIIKLEGSVELGPVVGLADAI
VDIVETGNTLSANGLEVIEKISDISTRMIVNKSSFKFKKDKIIEMVERLE
DAQ
Ligand information
Ligand IDPO4
InChIInChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
InChIKeyNBIIXXVUZAFLBC-UHFFFAOYSA-K
SMILES
SoftwareSMILES
CACTVS 3.341[O-][P]([O-])([O-])=O
ACDLabs 10.04[O-]P([O-])([O-])=O
OpenEye OEToolkits 1.5.0[O-]P(=O)([O-])[O-]
FormulaO4 P
NamePHOSPHATE ION
ChEMBL
DrugBankDB14523
ZINC
PDB chain1z7m Chain G Residue 209 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1z7m Activation of the hetero-octameric ATP phosphoribosyl transferase through subunit interface rearrangement by a tRNA synthetase paralog.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		E158 T159 N161 T162
Binding residue
(residue number reindexed from 1)		E155 T156 N158 T159
Annotation score1
Enzymatic activity
Enzyme Commision number 2.4.2.17: ATP phosphoribosyltransferase.
Gene Ontology
Molecular Function
GO:0003879 ATP phosphoribosyltransferase activity
GO:0005524 ATP binding
GO:0016757 glycosyltransferase activity
Biological Process
GO:0000105 L-histidine biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1z7m, PDBe:1z7m, PDBj:1z7m
PDBsum1z7m
PubMed16051603
UniProtQ02129|HIS1_LACLA ATP phosphoribosyltransferase (Gene Name=hisG)

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