Structure of PDB 1t44 Chain G Binding Site BS02

Receptor Information
>1t44 Chain G (length=144) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EHPEFLKAGKEPGLQIWRVEKFDLVPVPTNLYGDFFTGDAYVILKTVQLR
NGNLQYDLHYWLGNECSQDESGAAAIFTVQLDDYLNGRAVQHREVQGFES
ATFLGYFKSGLKYKKGGVASGFKHVETQEKNPLPSKETIEQEKQ
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain1t44 Chain G Residue 702 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1t44 Structural basis of actin sequestration by thymosin-beta4: implications for WH2 proteins.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		G65 D66 E97 V145
Binding residue
(residue number reindexed from 1)		G38 D39 E70 V118
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003785 actin monomer binding
GO:0051015 actin filament binding
Biological Process
GO:0007015 actin filament organization

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Molecular Function
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Biological Process
External links
PDB RCSB:1t44, PDBe:1t44, PDBj:1t44
PDBsum1t44
PubMed15329672
UniProtP06396|GELS_HUMAN Gelsolin (Gene Name=GSN)

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