Structure of PDB 1h1v Chain G Binding Site BS02

Receptor Information
>1h1v Chain G (length=327) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MDDDGTGQKQIWRIEGSNKVPVDPATYGQFYGGDSYIILYNYRHGQIIYN
WQGAQSTQDEVAASAILTAQLDEELGGTPVQSRVVQGKEPAHLMSLFGGK
PMIIYKGGTSREGGQTAPASTRLFQVRANSAGATRAVEVLPKAGALNSND
AFVLKTPSAAYLWVGTGASEAEKTGAQELLRVLRAQPVQVAEGSEPDGFW
EALGGKAAYRTSPRLKDKKMDAHPPRLFACSNKIGRFVIEEVPGELMQED
LATDDVMLLDTWDQVFVWVGKDSQEEEKTEALTSAKRYIETDPANRDRRT
PITVVKQGFEPPSFVGWFLGWDDDYWS
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain1h1v Chain G Residue 1744 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB1h1v The Calcium Activation of Gelsolin:Insights from the 3A Structure of the G4-G6/Actin Complex
Resolution2.99 Å
Binding residue
(original residue number in PDB)		G444 D445 E475 T524 S525
Binding residue
(residue number reindexed from 1)		G33 D34 E60 T109 S110
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0051015 actin filament binding

View graph for
Molecular Function
External links
PDB RCSB:1h1v, PDBe:1h1v, PDBj:1h1v
PDBsum1h1v
PubMed12460571
UniProtP06396|GELS_HUMAN Gelsolin (Gene Name=GSN)

[Back to BioLiP]