Structure of PDB 7zx0 Chain FFF Binding Site BS02

Receptor Information
>7zx0 Chain FFF (length=634) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SLSIIDVASDQNLFQTFIKEWRCKKRFSISLACEKIRDDGFPIKGCDDTL
VVGLAVCWGGRDAYYFSLQKEPPSLDPSLTLKDRMWYLQSCLRKESDKEC
SVVIYDFIQSYKILLLSCGISLEQSYEDPKVACWLLDPDSQEPTLHSIVT
SFLPHELPLLEGMETSQGIQSLGLNAGSEHSGRYRASVESILIFNSMNQL
NSLLQKENLQDVFRKVEMPSQYCLALLELNGIGFSTAECESQKHIMQAKL
DAIETQAYQLAGHSFSFTSSDDIAEVLFLELKLPPFSTSKDVLNKLKALH
PLPGLILEWRRITNAITKVVFPLQREKCLNPFLGMERIYPVSQSHTATGR
ITFTEPNIQNVPRDFEIKMGGMPFSISMRHAFVPFPGGSILAADYSQLEL
RILAHLSHDRRLIQVLNTGADVFRSIAAEWKMIEPESVGDDLRQQAKQIC
YGIIYGMGAKSLGEQMGIKENDAACYIDSFKSRYTGINQFMTETVKNCKR
DGFVQTILGRRRYLPGIKDNNPYRKAHAERQAINTIVQGSAADIVKIATV
NIQKQLETFHSTFKSHGHRECPIRGGFFILQLHDELLYEVAEEDVVQVAQ
IVKNEMESAVKLSVKLKVKVKIGASWGELKDFDV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7zx0 Discovery, Characterization, and Structure-Based Optimization of Small-Molecule In Vitro and In Vivo Probes for Human DNA Polymerase Theta.
Resolution2.99 Å
Binding residue
(original residue number in PDB)		R2201 N2205 K2209 R2241 Q2250 N2251 V2252 P2253 R2254 R2315 H2539
Binding residue
(residue number reindexed from 1)		R310 N314 K318 R350 Q359 N360 V361 P362 R363 R379 H583
Enzymatic activity
Enzyme Commision number 2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.6.4.12: DNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication

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Molecular Function
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Biological Process
External links
PDB RCSB:7zx0, PDBe:7zx0, PDBj:7zx0
PDBsum7zx0
PubMed36200480
UniProtO75417|DPOLQ_HUMAN DNA polymerase theta (Gene Name=POLQ)

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