Structure of PDB 8xj6 Chain F Binding Site BS02

Receptor Information
>8xj6 Chain F (length=676) Species: 10244 (Monkeypox virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IRGNDVIFVLKTIGVPSACRQNEDPRFVEAFKCDELERYIDNNPECTLFE
SLRDEEAYSIVRIFMDVDLDACLDEIDYLTAIQDFIIEVSNCVARFAFTE
CGAIHENVIKSMRSNFSLTKSTNRDKTSFHIIFLDTYTTMDTLIAMKRTL
LELSRSSENPLTRSIDTAVYRRKTTLRVVGTRKNPNCDTIHVMQPPHDNI
EDYLFTYVDMNNNSYYFSLQRRWEPGFISFEDAIKRVSKIFINSIINFND
LDENNFTTVPLVIDYVCALCKKRSHKHPHQLSLENGAIRIYKTGNPHSCK
VKIVPLDGNKLFNIAQRILDTNSVLLTERGDHIVWINNSWKFNSEEPLIT
KLILSIRHQLPKEYSSELLCPRKRKTVEANIRDMLVDSVETDTYPDKLPF
KNGVLDLVDGMFYSGDDAKKYTCTVSTGFKFDDTKFVEDSPEMEELMNII
NDIQPLTDENKKNRELYEKTLSSCLCGATKGCLTFFFGETATGKSTTKRL
LKSAIGDLFVETGQTILTDVNPFIANMHLKRSVFCSELPDFACSGSKKIR
SDNIKKLTEPCVIINNRNHATIIIDTNYKPVFDRIDNALMRRIAVVRFRT
HFSQPSGREAAENNDAYDKVKLLDEGLDGKIQNNRYRFAFLYLLVKWYKK
YHIPIMKLYPTPEEIPDFAFYLKIGT
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8xj6 Chain F Residue 802 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8xj6 Structural and functional insights into the helicase protein E5 of Mpox virus.
Resolution3.32 Å
Binding residue
(original residue number in PDB)		C282 C285 C314
Binding residue
(residue number reindexed from 1)		C267 C270 C299
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0016787 hydrolase activity
Cellular Component
GO:0030430 host cell cytoplasm

View graph for
Molecular Function
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Cellular Component
External links
PDB RCSB:8xj6, PDBe:8xj6, PDBj:8xj6
PDBsum8xj6
PubMed38914567
UniProtA0A7H0DN89|PG117_MONPV Uncoating factor OPG117 (Gene Name=OPG117)

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