Structure of PDB 8w8o Chain F Binding Site BS02

Receptor Information
>8w8o Chain F (length=346) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SDPVRQYLHEIGQVPLLTLEEEVELARKVEEGMEAIKKLSEITGLDPDLI
REVVRAKILGSARVRHIPGLKETLDPKTVEEIDQKLKSLPKEHKRYLHIA
REGEAARQHLIEANLRLVVSIAKKYTGRGLSFLDLIQEGNQGLIRAVEKF
EYKRRFKFSTYATWWIRQAINRAIADQARTIRIPVHMVETINKLSRTARQ
LQQELGREPTYEEIAEAMGPGWDAKRVEETLKIAQEPVSLETPIGDEKDS
FYGDFIPDEHLPSPVDAATQSLLSEELEKALSKLSEREAMVLKLRKGLID
GREHTLEEVGAFFGVTRERIRQIENKALRKLKYHESRTRKLRDFLD
Ligand information
Receptor-Ligand Complex Structure
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PDB8w8o Nanopore tweezers show fractional-nucleotide translocation in sequence-dependent pausing by RNA polymerase.
Resolution2.512 Å
Binding residue
(original residue number in PDB)		D79 V81 R82 L85 G89 N191 R193 L194 S197 K200 F209 K226 F227 E228 R231 F233 K234 S236 T237 Y238 W241
Binding residue
(residue number reindexed from 1)		D2 V4 R5 L8 G12 N114 R116 L117 S120 K123 F132 K149 F150 E151 R154 F156 K157 S159 T160 Y161 W164
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0016987 sigma factor activity
GO:0046872 metal ion binding
Biological Process
GO:0006352 DNA-templated transcription initiation
GO:0006355 regulation of DNA-templated transcription
GO:0010468 regulation of gene expression
GO:2000142 regulation of DNA-templated transcription initiation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8w8o, PDBe:8w8o, PDBj:8w8o
PDBsum8w8o
PubMed38990947
UniProtQ5SKW1

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