Structure of PDB 8pzy Chain F Binding Site BS02

Receptor Information
>8pzy Chain F (length=499) Species: 652611 (Pseudomonas aeruginosa PA14) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FQGGMEFLVKSVRPETLKTATLVLAVGEGRKLGASAKAVDDATGGAISAV
LKRGDLAGKVGQTLLLQSLPNLKAERVLLVGAGKERELGDRQYRKLASAV
LSTLKGLAGADAALALGDLAVKGRGAHAKARLLVETLADGLYVFDRYKSQ
KAEPLKLKKLTLLADKADSAAVEQGSKEAQAIANGMALTRDLGNLPPNVC
HPTFLGEQAKGLAKEFKSLKVEVLDEKKLRELGMGSFLAVAQGSDQPPRL
IILQYNGAKKDQAPHVLVGKGITFDTGGISLKPGLGMDEMKFDMCGAASV
FGTFRAVLELQLPINLVGLLACAENMPSGGATRPGDIVTTMSGQTVEILN
TDAEGRLVLCDALTYAERFKPQSVIDIATLTGACIVALGSNTSGLMGNNE
ALVRQLLKAGEFADDRAWQLPLFDEYQEQLDSPFADIANIGGPKAGTITA
GCFLSRFAKKYHWAHLDIAGTAWISGGKDKGATGRPVPLLTQYLLERAK
Ligand information
Ligand IDP03
InChIInChI=1S/C10H22O5/c11-3-9-14-7-1-5-13-6-2-8-15-10-4-12/h11-12H,1-10H2
InChIKeyGNAZJSIZGCDIQL-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.352OCCOCCCOCCCOCCO
OpenEye OEToolkits 1.7.0C(COCCCOCCO)COCCO
FormulaC10 H22 O5
Name2-[3-[3-(2-hydroxyethoxy)propoxy]propoxy]ethanol
ChEMBL
DrugBank
ZINCZINC000058633634
PDB chain8pzy Chain F Residue 606 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8pzy Unveiling the Catalytic Mechanism of a Processive Metalloaminopeptidase.
Resolution1.97 Å
Binding residue
(original residue number in PDB)		V43 G44 G46 R47 K48 L49
Binding residue
(residue number reindexed from 1)		V26 G27 G29 R30 K31 L32
Annotation score1
Enzymatic activity
Enzyme Commision number 3.4.11.1: leucyl aminopeptidase.
3.4.11.10: bacterial leucyl aminopeptidase.
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0008235 metalloexopeptidase activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
GO:0070006 metalloaminopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019538 protein metabolic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8pzy, PDBe:8pzy, PDBj:8pzy
PDBsum8pzy
PubMed37924287
UniProtQ02RY8|AMPA_PSEAB Probable cytosol aminopeptidase (Gene Name=pepA)

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