Structure of PDB 8phi Chain F Binding Site BS02

Receptor Information
>8phi Chain F (length=453) Species: 11259 (Human respiratory syncytial virus A2) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QNITEEFYQSTCSAVSKGYLSALRTGWYTSVITIELSNIKENKCDAKVKL
IKQELDKYKNAVTELQLLMQSFLGFLLGVGSAIASGVAVCKVLHLEGEVN
KIKSALLSTNKAVVSLSNGVSVLTFKVLDLKNYIDKQLLPILNKQSCSIS
NIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMP
ITNDQKKLMSNNVQIVRQQSYSIMCIIKEEVLAYVVQLPLYGVIDTPCWK
LHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRV
FCDTMNSLTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVS
CYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGK
SLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLSA
IGG
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain8phi Chain F Residue 605 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8phi Drug repurposing screen identifies lonafarnib as respiratory syncytial virus fusion protein inhibitor.
Resolution2.289 Å
Binding residue
(original residue number in PDB)		Y457 Y458
Binding residue
(residue number reindexed from 1)		Y392 Y393
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0019064 fusion of virus membrane with host plasma membrane

View graph for
Biological Process
External links
PDB RCSB:8phi, PDBe:8phi, PDBj:8phi
PDBsum8phi
PubMed38332002
UniProtP03420|FUS_HRSVA Fusion glycoprotein F0 (Gene Name=F)

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