Structure of PDB 8k60 Chain F Binding Site BS02

Receptor Information
>8k60 Chain F (length=315) Species: 100226 (Streptomyces coelicolor A3(2)) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DEDDAPAQQVAAAGATADPVKDYLKQIGKVPLLNAEQEVELAKRIEAGLF
AEDKLANSDKLAPKLKRELEIIAEDGRRAKNHLLEANLRLVVSLAKRYTG
RGMLFLDLIQEGNLGLIRAVEKFDYTKGYKFSTYATWWIRQAITRAMADQ
ARTIRIPVHMVEVINKLARVQRQMLQDLGREPTPEELAKELDMTPEKVIE
VQKYGREPISLHTPLGEDGDSEFGDLIEDSEAVVPADAVSFTLLQEQLHS
VLDTLSEREAGVVSMRFGLTDGQPKTLDEIGKVYGVTRERIRQIESKTMS
KLRHPSRSQVLRDYL
Ligand information
>8k60 Chain H (length=57) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
tgcatccgtgagtcgagggtaataaccagggggagataaacgaacgctga
acgctcc
Receptor-Ligand Complex Structure
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PDB8k60 Structural insights into transcription activation of the Streptomyces antibiotic regulatory protein, AfsR
Resolution3.4 Å
Binding residue
(original residue number in PDB)		Y293 R296 W332 P403 I404 E412 D413 L421
Binding residue
(residue number reindexed from 1)		Y98 R101 W137 P208 I209 E217 D218 L226
Gene Ontology
Molecular Function
GO:0001108 bacterial-type RNA polymerase holo enzyme binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0016987 sigma factor activity
Biological Process
GO:0006352 DNA-templated transcription initiation
GO:0006355 regulation of DNA-templated transcription
GO:0010468 regulation of gene expression
GO:2000142 regulation of DNA-templated transcription initiation
Cellular Component
GO:0005737 cytoplasm

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Biological Process
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Cellular Component
External links
PDB RCSB:8k60, PDBe:8k60, PDBj:8k60
PDBsum8k60
PubMed39108719
UniProtP18183|SIGA_STRCO RNA polymerase principal sigma factor HrdB (Gene Name=hrdB)

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