Structure of PDB 8hsj Chain F Binding Site BS02

Receptor Information

>8hsj Chain F (length=361) Species: 300852 (Thermus thermophilus HB8)

RLVKGYLEISQDGYGFLTENLHNLESRVAIVSAGLIKQYALRAGDYVVGQ
ARPPRENERYATLLKVEAVNNLDPEAAKNRPRFDELTPQFPDRQIRLETT
PDELSTRVIDLLAPIGRGQRGLIVAPPKAGKTTLLKKIANAVLKNEPDIK
VIVLLIDERPEEVTDFRESVQGAEVIASTFDEPPQNHIRVAEFVHERAKR
IVEEGGHVMILLDSITRLARANNLVTPPTGRTLSGGLDSAALYFPKRFLG
AARNIRGGGSLTILATALVETGSRMDDVIFEEFKGTGNMELHLSRRLEER
RIFPAIDILKSGTRREELLLGEEVTHKMWLLRKVLADMDPAEAMEMLLAR
LARTKNNKEFL

Ligand information

• Ligand ID: BEF
• InChI: InChI=1S/Be.3FH/h;3*1H/q+2;;;/p-3
• InChIKey: OGIAHMCCNXDTIE-UHFFFAOYSA-K
• SMILES:
  OpenEye OEToolkits 1.5.0: [Be-](F)(F)F
  ACDLabs 10.04
  CACTVS 3.341: F[Be-](F)F
• Formula: Be F3
• Name: BERYLLIUM TRIFLUORIDE ION
• PDB chain: 8hsj Chain F Residue 1002

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8hsj Structural basis of the transcription termination factor Rho engagement with transcribing RNA polymerase from Thermus thermophilus.
• Resolution: 3.6 Å
• Binding residue (original residue number in PDB): P186 K187 K190
• Binding residue (residue number reindexed from 1): P127 K128 K131
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.6.4.-

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0004386 helicase activity
• GO:0005524 ATP binding
• GO:0008186 ATP-dependent activity, acting on RNA
• GO:0016787 hydrolase activity
• GO:0016887 ATP hydrolysis activity

Biological Process

• GO:0006353 DNA-templated transcription termination

External links

• PDB: RCSB:8hsj, PDBe:8hsj, PDBj:8hsj
• PDBsum: 8hsj
• PubMed: 36753546
• UniProt: Q5SJE9