Structure of PDB 8b9z Chain F Binding Site BS02

Receptor Information
>8b9z Chain F (length=441) Species: 7227 (Drosophila melanogaster) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PPPGTPPPQTKTKFGPLADEDRIFTNLYGRHDWRLKGALKRGDWYKTKEI
VLKGADWIVNEIKTSGLRGRGGAGFPSGMKWSFMNKPGDGRPKYLVVNAD
EGEPGTCKDREIMRHDPHKLVEGCLIAGRAMGAQAAYIYIRGEFYNEASN
MQLAIAEAYQAGLIGKNACGTGYDFDVFMHRGAGAYICGEETALIESLEG
KQGKPRLKPPFPADVGVFGCPTTVTNVETVAVAPTICRRGGVWFASFGRT
RNSGTKLFNISGHVNRPCTVEEEMSIPLKELIERHCGGVTGGWDNLLGVI
PGGSSTPIIPKNVCDDVIMDFDGLIAAQTSLGTAAIIVMDKSTDVIKAIA
RLISFYKHESCGQCTPCREGIGWMNKIMTRFVKGDAQPAEIDMLWEISKQ
IEGHTICALGDGAAWPVQGLIRHFRPEIEKRMQLHAKRVSN
Ligand information
Ligand IDSF4
InChIInChI=1S/4Fe.4S
InChIKeyLJBDFODJNLIPKO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7[S]12[Fe]3[S]4[Fe]1[S]5[Fe]2[S]3[Fe]45
CACTVS 3.385S1[Fe]S[Fe]1.S2[Fe]S[Fe]2
FormulaFe4 S4
NameIRON/SULFUR CLUSTER
ChEMBL
DrugBank
ZINC
PDB chain8b9z Chain F Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8b9z Cryo-EM structures of mitochondrial respiratory complex I from Drosophila melanogaster.
Resolution3.28 Å
Binding residue
(original residue number in PDB)		P238 C394 G395 Q396 C397 C400 T438 C440 L442
Binding residue
(residue number reindexed from 1)		P205 C361 G362 Q363 C364 C367 T405 C407 L409
Annotation score1
Enzymatic activity
Enzyme Commision number 7.1.1.2: NADH:ubiquinone reductase (H(+)-translocating).
Gene Ontology
Molecular Function
GO:0008137 NADH dehydrogenase (ubiquinone) activity
GO:0010181 FMN binding
GO:0046872 metal ion binding
GO:0051287 NAD binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0006120 mitochondrial electron transport, NADH to ubiquinone
GO:1902600 proton transmembrane transport
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0045271 respiratory chain complex I

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8b9z, PDBe:8b9z, PDBj:8b9z
PDBsum8b9z
PubMed36622099
UniProtQ9VMI3

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