Structure of PDB 7x75 Chain F Binding Site BS02

Receptor Information

>7x75 Chain F (length=301) Species: 100226 (Streptomyces coelicolor A3(2))

ATADPVKDYLKQIGKVPLLNAEQEVELAKRIEAGLFAEDKLANSDKLAPK
LKRELEIIAEDGRRAKNHLLEANLRLVVSLAKRYTGRGMLFLDLIQEGNL
GLIRAVEKFDYTKGYKFSTYATWWIRQAITRAMADQARTIRIPVHMVEVI
NKLARVQRQMLQDLGREPTPEELAKELDMTPEKVIEVQKYGREPISLHTP
LGEDGDSEFGDLIEDSEAVVPADAVSFTLLQEQLHSVLDTLSEREAGVVS
MRFGLTDGQPKTLDEIGKVYGVTRERIRQIESKTMSKLRHPSRSQVLRDY
L

Ligand information

>7x75 Chain P (length=84)

ggcgacccggcgcccgctacggagtcaactacgggtagggggtatcgggc
aacgcggcactgaacaccgttgtcatgtgccttg

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7x75 Structural basis of Streptomyces transcription activation by zinc uptake regulator.
• Resolution: 3.45 Å
• Binding residue (original residue number in PDB): R292 R296 E357 R364 R367 E412 L472 D473 E474 R483 E484 R487
• Binding residue (residue number reindexed from 1): R83 R87 E148 R155 R158 E203 L263 D264 E265 R274 E275 R278

Gene Ontology

Molecular Function

• GO:0001108 bacterial-type RNA polymerase holo enzyme binding
• GO:0003677 DNA binding
• GO:0003700 DNA-binding transcription factor activity
• GO:0005515 protein binding
• GO:0016987 sigma factor activity

Biological Process

• GO:0006352 DNA-templated transcription initiation
• GO:0006355 regulation of DNA-templated transcription
• GO:0010468 regulation of gene expression
• GO:2000142 regulation of DNA-templated transcription initiation

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:7x75, PDBe:7x75, PDBj:7x75
• PDBsum: 7x75
• PubMed: 35871291
• UniProt: P18183|SIGA_STRCO RNA polymerase principal sigma factor HrdB (Gene Name=hrdB)