Structure of PDB 7wm4 Chain F Binding Site BS02

Receptor Information

>7wm4 Chain F (length=668) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

QCTVRYNVADCSHLKLTHIPDDLPSNITVLNLTHNQLRRLPPTNFTRYSQ
LAILDAGFNSISKLEPELCQILPLLKVLNLQHNELSQISDQTFVFCTNLT
ELDLMSNSIHKIKSNPFKNQKNLIKLDLSHNGLSSTKLGTGVQLENLQEL
LLAKNKILALRSEELEFLGNSSLRKLDLSSNPLKEFSPGCFQTIGKLFAL
LLNNAQLNPHLTEKLCWELSNTSIQNLSLANNQLLATSESTFSGLKWTNL
TQLDLSYNNLHDVGNGSFSYLPSLRYLSLEYNNIQRLSPRSFYGLSNLRY
LSLKRAFTKQSVSLASHPNIDDFSFQWLKYLEYLNMDDNNIPSTKSNTFT
GLVSLKYLSLSKTFTSLQTLTNETFVSLAHSPLLTLNLTKNHISKIANGT
FSWLGQLRILDLGLNEIEQKLSGQEWRGLRNIFEIYLSYNKYLQLSTSSF
ALVPSLQRLMLRRVALKNVDISPSPFRPLRNLTILDLSNNNIANINEDLL
EGLENLEILDFQHNNLARLWNPGGPVNFLKGLSHLHILNLESNGLDEIPV
GVFKNLFELKSINLGLNNLNKLEPFIFDDQTSLRSLNLQKNLITSVEKDV
FGPPFQNLNSLDMRFNPFDCTCESISWFVNWINQTHTNISELSTHYLCNT
PHHYYGFPLKLFDTSSCK

Ligand information

>7wm4 Chain B (length=81) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

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Receptor-Ligand Complex Structure

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Structure summary

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PDB	7wm4 TLR3 forms a laterally aligned multimeric complex along double-stranded RNA for efficient signal transduction.
Resolution	3.2 Å
Binding residue (original residue number in PDB)	R65 E111 S113 N518 H540 N542 G574
Binding residue (residue number reindexed from 1)	R38 E84 S86 N491 H513 N515 G544

Enzymatic activity

Enzyme Commision number

External links

PDB	RCSB:7wm4, PDBe:7wm4, PDBj:7wm4
PDBsum	7wm4
PubMed	36631495
UniProt	Q99MB1\|TLR3_MOUSE Toll-like receptor 3 (Gene Name=Tlr3)

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