Structure of PDB 7w4p Chain F Binding Site BS02

Receptor Information
>7w4p Chain F (length=1401) Species: 10036 (Mesocricetus auratus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PLAFCGTENHSAAYRVDQGVLNNGCFVDALNVVPHVFLLFITFPILFIGH
HSTWLHFPGHNLRWILTFILLFVLVCEIAEGILSDGVTESRHLHLYMPAG
MAFMAAITSVVYYHNIETSNFPKLLIALLIYWTLAFITKTIKFVKFYDHA
IGFSQLRFCLTGLLVILYGMLLLVEVNVIRVRRYIFFKTPREVKPPEDLQ
DLGVRFLQPFVNLLSKGTYWWMNAFIKTAHKKPIDLRAIGKLPIAMRALT
NYQRLCVAFDAQARPQGARAIWRALCHAFGRRLILSSTFRILADLLGFAG
PLCIFGIVDHLGKKTQFLGVYFVSSQEFLGNAYVLAVLLFLALLLQRTFL
QASYYVAIETGINLRGAIQTKIYNKIMHLSTSNLSMGEMTAGQICNLVAI
DTNQLMWFFFLCPNLWAMPVQIIVGVILLYYILGVSALIGAAVIILLAPV
QYFVATKLSQAQRSTLEHSNERLKQTNEMLRGMKLLKLYAWESIFCSRVE
VTRRKEMTSLRAFAVYTSISIFMNTAIPIAAVLITFVGHVSFFKESDLSP
SVAFASLSLFHILVTPLFLLSSVVRSTVKALVSVQKLSEFLSSAEIREDN
FCVQIIGGFFTWTPDGIPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLAT
LGEMQKVSGAVFWNSSRGPVAYASQKPWLLNATVEENITFESPFNKQRYK
MVIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQQTNV
VFLDDPFSALDVHLSDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWI
IAMKDGTIQREGTLKDFQRSECQLFEHWKTLMNELEKERACTKYLSSAGI
LLLSLLVFSQLLKHMVLVAIDYWLAKWTDSDQSVYAMVFTLLCSLGIVLC
LVTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDC
NTIDQHIPSTLECLSRSTLLCVSALTVISYVTPVFLVALLPLAVVCYFIQ
KYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARFQQKLLE
YTDSNNIASLFLTAANRWLEVRMEYIGACVVLIAAATSISNSLHRELSAG
LVGLGLTYALMVSNYLNWMVRNLADMEIQLGAVKRIHALLKTEAESYEGL
LAPSLIPKNWPDQGKIQIQNLSVRYDSSLKPVLKHVNALISPGQKIGICG
RTGSGKSSFSLAFFRMVDMFEGRIIIDGIDIAKLPLHTLRSRLSIILQDP
VLFSGTIRFNLDPEKKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGG
ENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFA
DRTVVTIAHRVHTILSADLVMVLKRGAILEFDKPETLLSQKDSVFASFVR
A
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain7w4p Chain F Residue 1602 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7w4p Structural insights into the mechanism of pancreatic K ATP channel regulation by nucleotides.
Resolution3.19 Å
Binding residue
(original residue number in PDB)		S720 Q775 D854
Binding residue
(residue number reindexed from 1)		S644 Q675 D754
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005267 potassium channel activity
GO:0005524 ATP binding
GO:0008281 sulfonylurea receptor activity
GO:0016887 ATP hydrolysis activity
GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity
GO:0042626 ATPase-coupled transmembrane transporter activity
GO:0043531 ADP binding
GO:0044325 transmembrane transporter binding
GO:0140359 ABC-type transporter activity
Biological Process
GO:0001508 action potential
GO:0006813 potassium ion transport
GO:0031669 cellular response to nutrient levels
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0046676 negative regulation of insulin secretion
GO:0050905 neuromuscular process
GO:0055085 transmembrane transport
GO:0061535 glutamate secretion, neurotransmission
GO:0071805 potassium ion transmembrane transport
GO:0098655 monoatomic cation transmembrane transport
GO:0098662 inorganic cation transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0008282 inward rectifying potassium channel
GO:0016020 membrane
GO:0032991 protein-containing complex
GO:0098793 presynapse

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Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7w4p, PDBe:7w4p, PDBj:7w4p
PDBsum7w4p
PubMed35589716
UniProtA0A1U7R319

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