Structure of PDB 7vwy Chain F Binding Site BS02

Receptor Information
>7vwy Chain F (length=483) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RTTDPVRMYMREMGTVELLTREGEIDIAKRIEDGINQVQCSVAEYPEAIT
YLLEQYDRVEAEEARLSDLITGFVDPNAENSIDPELAREKFAELRAQYVV
TRDTIKAKGRSHATAQEEILKLSEVFKQFRLVPKQFDYLVNSMRVMMDRV
RTQERLIMKLCVEQCKMPKKNFITLFTGNETSDTWFNAAIAMNKPWSEKL
HDVSEEVHRALQKLQQIEEETGLTIEQVKDINRRMSIGEAKARRAKKEMV
EANLRLVISIAKKYTNRGLQFLDLIQEGNIGLMKAVDKFEYRRGYKFSTY
ATWWIRQAITRSIADQARTIRIPVHMIETINKLNRISRQMLQEMGREPTP
EELAERMLMPEDKIRKVLKIAKEPISMETPIGDDEDSHLGDFIEDTTLEL
PLDSATTESLRAATHDVLAGLTAREAKVLRMRFGIDMNTDYTLEEVGKQF
DVTRERIRQIEAKALRKLRHPSRSEVLRSFLDD
Ligand information
>7vwy Chain 2 (length=64) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
tgcatccgtgagtcgagggtaataagttgcgagtgaaggttttgttttga
cattcagtgctgtc
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7vwy Structural basis of transcription activation by Rob, a pleiotropic AraC/XylS family regulator.
Resolution4.57 Å
Binding residue
(original residue number in PDB)		N396 R397 N461 R468 K502 I511 D513 R562 L573 R588
Binding residue
(residue number reindexed from 1)		N266 R267 N331 R338 K372 I381 D383 R432 L443 R458
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005515 protein binding
GO:0016987 sigma factor activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0006352 DNA-templated transcription initiation
GO:0006355 regulation of DNA-templated transcription
GO:0009408 response to heat
GO:0010468 regulation of gene expression
GO:0045892 negative regulation of DNA-templated transcription
GO:2000142 regulation of DNA-templated transcription initiation
Cellular Component
GO:0000345 cytosolic DNA-directed RNA polymerase complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:1903865 sigma factor antagonist complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7vwy, PDBe:7vwy, PDBj:7vwy
PDBsum7vwy
PubMed35641097
UniProtP00579|RPOD_ECOLI RNA polymerase sigma factor RpoD (Gene Name=rpoD)

[Back to BioLiP]