Structure of PDB 7msz Chain F Binding Site BS02

Receptor Information

>7msz Chain F (length=178) Species: 83332 (Mycobacterium tuberculosis H37Rv)

QPRLKERYRSEIRDALRKQFGYGNVMQIPTVTKVVVNMGVGEAARDAKLI
NGAVNDLALITGQKPEVRRARKSIAQFKLREGMPVGVRVTLRGDRMWEFL
DRLTSIALPRIRDFRGLSPKQFDGVGNYTFGLAEQAVFHEVDVDKIDRVR
GMDINVVTSAATDDEGRALLRALGFPFK

Ligand information

>7msz Chain B (length=115)

uuacggcggccacagcggcagggaaacgcccggucccauuccgaacccgg
aagcuaagccugccagcgccgaugauacugccccuccggguggaaaagua
ggacaccgccgaaca

<..<<<<<<.....<<<<<<<<.....<<<<<...............>>>
..>>....>>>>>>.>>.<<........<<<<<....>>>>>........
>>...>>>>>>.>..

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7msz Interplay between an ATP-binding cassette F protein and the ribosome from Mycobacterium tuberculosis.
• Resolution: 3.1 Å
• Binding residue (original residue number in PDB): N31 Q34 Q70 K71 E73 R95 V96 T97 R99 R102
• Binding residue (residue number reindexed from 1): N24 Q27 Q63 K64 E66 R88 V89 T90 R92 R95

Gene Ontology

Molecular Function

• GO:0000049 tRNA binding
• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0005886 plasma membrane
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7msz, PDBe:7msz, PDBj:7msz
• PDBsum: 7msz
• PubMed: 35064151
• UniProt: P9WH83|RL5_MYCTU Large ribosomal subunit protein uL5 (Gene Name=rplE)