Structure of PDB 7mqs Chain F Binding Site BS02

Receptor Information

>7mqs Chain F (length=811) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

HLYPGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLS
FPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVH
LKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKD
DNEECGDICPGTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEG
LCCHSECLGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVN
FSFCQDLHHKCKNSRCHQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPC
PKVCHLLEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANL
GLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNL
RQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIA
LKTNGDQASCENELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYK
EAPYQNVTEFSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKPWTQYAIFVK
TLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKP
PSDPNGNITHYLVFWERQAEDSELFELDYCLKGLKLPSRLEESSFRKTFE
DYLHEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDTPEERCSVAA
YVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSY
RRYGDEELHLCVSRKHFALERGCRLRGLSPGNYSVRIRATSLAGNGSWTE
PTYFYVTDYLD

Ligand information

>7mqs Chain B (length=16) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

HLCGSELVEALYLVCL

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7mqs Symmetric and asymmetric receptor conformation continuum induced by a new insulin.
Resolution	4.4 Å
Binding residue (original residue number in PDB)	R479 K484 R554 R702
Binding residue (residue number reindexed from 1)	R471 K476 R537 R646

Enzymatic activity

Enzyme Commision number

2.7.10.1: receptor protein-tyrosine kinase.

External links

PDB	RCSB:7mqs, PDBe:7mqs, PDBj:7mqs
PDBsum	7mqs
PubMed	35289328
UniProt	P06213\|INSR_HUMAN Insulin receptor (Gene Name=INSR)

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