Structure of PDB 7khi Chain F Binding Site BS02

Receptor Information
>7khi Chain F (length=556) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QSQLKLLVTRGKEQGYLTYAEVNDHLPEDIVDSDQIEDIIQMINDMGIQV
MEEAPDADDLMLAENTADEDAAEAAAQVLSSVESEIGRTTDPVRMYMREM
GTVELLTREGEIDIAKRIEDGINQVQCSVAEYPEAITYLLEQYDRVEAEE
ARLSDLITGFVDDPELAREKFAELRAQYVVTRDTIKATAQEEILKLSEVF
KQFRLVPKQFDYLVNSMRVMMDRVRTQERLIMKLCVEQCKMPKKNFITLF
TGNETSDTWFNAAIAMNKPWSEKLHDVSEEVHRALQKLQQIEEETGLTIE
QVKDINRRMSIGEAKARRAKKEMVEANLRLVISIAKKYTNRGLQFLDLIQ
EGNIGLMKAVDKFEYRRGYKFSTYATWWIRQAITRSIADQARTIRIPVHM
IETINKLNRISRQMLQEMGREPTPEELAERMLMPEDKIRKVLKIAKEPIS
METPIGDDEDSHLGDFIEDTTLELPLDSATTESLRAATHDVLAGLTAREA
KVLRMRFGIDMNTDYTLEEVGKQFDVTRERIRQIEAKALRKLRHPSRSEV
LRSFLD
Ligand information
Receptor-Ligand Complex Structure
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PDB7khi Structural basis of ribosomal RNA transcription regulation.
Resolution3.62 Å
Binding residue
(original residue number in PDB)		W433 R436 E458 R465 R562 R588
Binding residue
(residue number reindexed from 1)		W377 R380 E402 R409 R506 R532
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005515 protein binding
GO:0016987 sigma factor activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0006352 DNA-templated transcription initiation
GO:0006355 regulation of DNA-templated transcription
GO:0009408 response to heat
GO:0010468 regulation of gene expression
GO:0045892 negative regulation of DNA-templated transcription
GO:2000142 regulation of DNA-templated transcription initiation
Cellular Component
GO:0000345 cytosolic DNA-directed RNA polymerase complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:1903865 sigma factor antagonist complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7khi, PDBe:7khi, PDBj:7khi
PDBsum7khi
PubMed33483500
UniProtP00579|RPOD_ECOLI RNA polymerase sigma factor RpoD (Gene Name=rpoD)

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