Structure of PDB 7khc Chain F Binding Site BS02

Receptor Information
>7khc Chain F (length=447) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GEIDIAKRIEDGINQVQCSVAEYPEAITYLLEQYDRVEAEEARLSDLITG
FVDDPELAREKFAELRAQYVVTRDTIKATAQEEILKLSEVFKQFRLVPKQ
FDYLVNSMRVMMDRVRTQERLIMKLCVEQCKMPKKNFITLFTGNETSDTW
FNAAIAMNKPWSEKLHDVSEEVHRALQKLQQIEEETGLTIEQVKDINRRM
SIGEAKARRAKKEMVEANLRLVISIAKKYTNRGLQFLDLIQEGNIGLMKA
VDKFEYRRGYKFSTYATWWIRQAITRSIADQARTIRIPVHMIETINKLNR
ISRQMLQEMGREPTPEELAERMLMPEDKIRKVLKIAKEPISMETPIGDDE
DSHLGDFIEDTTLELPLDSATTESLRAATHDVLAGLTAREAKVLRMRFGI
DMNTDYTLEEVGKQFDVTRERIRQIEAKALRKLRHPSRSEVLRSFLD
Ligand information
>7khc Chain Y (length=63) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
agtggtggcgcattatagggagttattccggcctgacaagaggaaattta
aaataattttctg
Receptor-Ligand Complex Structure
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PDB7khc Structural basis of ribosomal RNA transcription regulation.
Resolution4.14 Å
Binding residue
(original residue number in PDB)		Y425 K426 T429 R562 T572 E574 E585 R588
Binding residue
(residue number reindexed from 1)		Y260 K261 T264 R397 T407 E409 E420 R423
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005515 protein binding
GO:0016987 sigma factor activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0006352 DNA-templated transcription initiation
GO:0006355 regulation of DNA-templated transcription
GO:0009408 response to heat
GO:0010468 regulation of gene expression
GO:0045892 negative regulation of DNA-templated transcription
GO:2000142 regulation of DNA-templated transcription initiation
Cellular Component
GO:0000345 cytosolic DNA-directed RNA polymerase complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:1903865 sigma factor antagonist complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7khc, PDBe:7khc, PDBj:7khc
PDBsum7khc
PubMed33483500
UniProtP00579|RPOD_ECOLI RNA polymerase sigma factor RpoD (Gene Name=rpoD)

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