Structure of PDB 7khb Chain F Binding Site BS02

Receptor Information
>7khb Chain F (length=471) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IGRTTDPVRMYMREMGTVELLTREGEIDIAKRIEDGINQVQCSVAEYPEA
ITYLLEQYDRVEAEEARLSDLITGFVDDPELAREKFAELRAQYVVTRDTI
KATAQEEILKLSEVFKQFRLVPKQFDYLVNSMRVMMDRVRTQERLIMKLC
VEQCKMPKKNFITLFTGNETSDTWFNAAIAMNKPWSEKLHDVSEEVHRAL
QKLQQIEEETGLTIEQVKDINRRMSIGEAKARRAKKEMVEANLRLVISIA
KKYTNRGLQFLDLIQEGNIGLMKAVDKFEYRRGYKFSTYATWWIRQAITR
SIADQARTIRIPVHMIETINKLNRISRQMLQEMGREPTPEELAERMLMPE
DKIRKVLKIAKEPISMETPIGDDEDSHLGDFIEDTTLELPLDSATTESLR
AATHDVLAGLTAREAKVLRMRFGIDMNTDYTLEEVGKQFDVTRERIRQIE
AKALRKLRHPSRSEVLRSFLD
Ligand information
>7khb Chain Y (length=64) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ctcgtagagtccgtgtcagtggtggcgcattatagggagttattccggcc
tgacaagaggaaat
Receptor-Ligand Complex Structure
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PDB7khb Structural basis of ribosomal RNA transcription regulation.
Resolution3.53 Å
Binding residue
(original residue number in PDB)		Y394 N396 R397 R436 Q437 I505 T509 I511 G512 D514 R562 T572 L573 E585 R588
Binding residue
(residue number reindexed from 1)		Y253 N255 R256 R295 Q296 I364 T368 I370 G371 D373 R421 T431 L432 E444 R447
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005515 protein binding
GO:0016987 sigma factor activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0006352 DNA-templated transcription initiation
GO:0006355 regulation of DNA-templated transcription
GO:0009408 response to heat
GO:0010468 regulation of gene expression
GO:0045892 negative regulation of DNA-templated transcription
GO:2000142 regulation of DNA-templated transcription initiation
Cellular Component
GO:0000345 cytosolic DNA-directed RNA polymerase complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:1903865 sigma factor antagonist complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7khb, PDBe:7khb, PDBj:7khb
PDBsum7khb
PubMed33483500
UniProtP00579|RPOD_ECOLI RNA polymerase sigma factor RpoD (Gene Name=rpoD)

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