Structure of PDB 7c97 Chain F Binding Site BS02

Receptor Information
>7c97 Chain F (length=472) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EIGRTTDPVRMYMREMGTVELLTREGEIDIAKRIEDGINQVQCSVAEYPE
AITYLLEQYDRVEAEEARLSDLITGFVDDPELAREKFAELRAQYVVTRDT
IKATAQEEILKLSEVFKQFRLVPKQFDYLVNSMRVMMDRVRTQERLIMKL
CVEQCKMPKKNFITLFTGNETSDTWFNAAIAMNKPWSEKLHDVSEEVHRA
LQKLQQIEEETGLTIEQVKDINRRMSIGEAKARRAKKEMVEANLRLVISI
AKKYTNRGLQFLDLIQEGNIGLMKAVDKFEYRRGYKFSTYATWWIRQAIT
RSIADQARTIRIPVHMIETINKLNRISRQMLQEMGREPTPEELAERMLMP
EDKIRKVLKIAKEPISMETPIGDDEDSHLGDFIEDTTLELPLDSATTESL
RAATHDVLAGLTAREAKVLRMRFGIDMNTDYTLEEVGKQFDVTRERIRQI
EAKALRKLRHPSRSEVLRSFLD
Ligand information
>7c97 Chain G (length=48) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ccctgcatccgtgatagacaatttaacacttttgtcaatcattttgtt
Receptor-Ligand Complex Structure
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PDB7c97 Structural basis for transcription inhibition by E. coli SspA
Resolution3.68 Å
Binding residue
(original residue number in PDB)		Y394 R397 R465 R562 L573 E585
Binding residue
(residue number reindexed from 1)		Y254 R257 R325 R422 L433 E445
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005515 protein binding
GO:0016987 sigma factor activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0006352 DNA-templated transcription initiation
GO:0006355 regulation of DNA-templated transcription
GO:0009408 response to heat
GO:0010468 regulation of gene expression
GO:0045892 negative regulation of DNA-templated transcription
GO:2000142 regulation of DNA-templated transcription initiation
Cellular Component
GO:0000345 cytosolic DNA-directed RNA polymerase complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:1903865 sigma factor antagonist complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7c97, PDBe:7c97, PDBj:7c97
PDBsum7c97
PubMed
UniProtP00579|RPOD_ECOLI RNA polymerase sigma factor RpoD (Gene Name=rpoD)

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