Structure of PDB 7c17 Chain F Binding Site BS02

Receptor Information
>7c17 Chain F (length=465) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RTTDPVRMYMREMGTVELLTREGEIDIAKRIEDGINQVQCSVAEYPEAIT
YLLEQYDRVEAENSIDPELAREKFAELRAQYVVTRDTIKAKGRSHATAQE
EILKLSEVFKQFRLVPKQFDYLVNSMRVMMDRVRTQERLIMKLCVEQCKM
PKKNFITLFTGNETSDTWFNAAIAMNKPWSEKLHDVSEEVHRALQKLQQI
EEETGLTIEQVKDINRRMSIGEAKARRAKKEMVEANLRLVISIAKKYTNR
GLQFLDLIQEGNIGLMKAVDKFEYRRGYKFSTYATWWIRQAITRSIADQA
RTIRIPVHMIETINKLNRISRQMLQEMGREPTPEELAERMLMPEDKIRKV
LKIAKEPISMETPIGDDEDSHLGDFIEDTTLELPLDSATTESLRAATHDV
LAGLTAREAKVLRMRFGIDMNTDYTLEEVGKQFDVTRERIRQIEAKALRK
LRHPSRSEVLRSFLD
Ligand information
>7c17 Chain 2 (length=46) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcatccgtgacaaaccttccagcaaggggaaggtcaagaaattaat
Receptor-Ligand Complex Structure
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PDB7c17 CueR activates transcription through a DNA distortion mechanism.
Resolution4.22 Å
Binding residue
(original residue number in PDB)		W433 R436 Q437 T440 E458 R465 R562 T572 R584 R588
Binding residue
(residue number reindexed from 1)		W286 R289 Q290 T293 E311 R318 R415 T425 R437 R441
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005515 protein binding
GO:0016987 sigma factor activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0006352 DNA-templated transcription initiation
GO:0006355 regulation of DNA-templated transcription
GO:0009408 response to heat
GO:0010468 regulation of gene expression
GO:0045892 negative regulation of DNA-templated transcription
GO:2000142 regulation of DNA-templated transcription initiation
Cellular Component
GO:0000345 cytosolic DNA-directed RNA polymerase complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:1903865 sigma factor antagonist complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7c17, PDBe:7c17, PDBj:7c17
PDBsum7c17
PubMed32989300
UniProtP00579|RPOD_ECOLI RNA polymerase sigma factor RpoD (Gene Name=rpoD)

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