Structure of PDB 6xlj Chain F Binding Site BS02

Receptor Information
>6xlj Chain F (length=476) Species: 83334 (Escherichia coli O157:H7) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SEIGRTTDPVRMYMREMGTVELLTREGEIDIAKRIEDGINQVQCSVAEYP
EAITYLLEQYDRVEAEEARLSDLITGFVDIDPELAREKFAELRAQYVVTR
DTIKHATAQEEILKLSEVFKQFRLVPKQFDYLVNSMRVMMDRVRTQERLI
MKLCVEQCKMPKKNFITLFTGNETSDTWFNAAIAMNKPWSEKLHDVSEEV
HRALQKLQQIEEETGLTIEQVKDINRRMSIGEAKARRAKKEMVEANLRLV
ISIAKKYTNRGLQFLDLIQEGNIGLMKAVDKFEYRRGYKFSTYATWWIRQ
AITRSIADQARTIRIPVHMIETINKLNRISRQMLQEMGREPTPEELAERM
LMPEDKIRKVLKIAKEPISMETPIGDDEDSHLGDFIEDTTLELPLDSATT
ESLRAATHDVLAGLTAREAKVLRMRFGIDMNTDYTLEEVGKQFDVTRERI
RQIEAKALRKLRHPSRSEVLRSFLDD
Ligand information
>6xlj Chain T (length=54) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cgccgcgtcagactgcacacaatctaaaccctccccttaggggagggtca
aggc
Receptor-Ligand Complex Structure
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PDB6xlj Structural visualization of transcription activated by a multidrug-sensing MerR family regulator.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		N396 R397 R468 I511 G512 D514 R562 T572 L573 R584 E585 R588
Binding residue
(residue number reindexed from 1)		N259 R260 R331 I374 G375 D377 R425 T435 L436 R447 E448 R451
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005515 protein binding
GO:0016987 sigma factor activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0006352 DNA-templated transcription initiation
GO:0006355 regulation of DNA-templated transcription
GO:0009408 response to heat
GO:0010468 regulation of gene expression
GO:0045892 negative regulation of DNA-templated transcription
GO:2000142 regulation of DNA-templated transcription initiation
Cellular Component
GO:0000345 cytosolic DNA-directed RNA polymerase complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:1903865 sigma factor antagonist complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6xlj, PDBe:6xlj, PDBj:6xlj
PDBsum6xlj
PubMed33976201
UniProtP00579|RPOD_ECOLI RNA polymerase sigma factor RpoD (Gene Name=rpoD)

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