Structure of PDB 6xl9 Chain F Binding Site BS02

Receptor Information
>6xl9 Chain F (length=465) Species: 83334 (Escherichia coli O157:H7) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GRTTDPVRMYMREMGTVELLTREGEIDIAKRIEDGINQVQCSVAEYPEAI
TYLLEQYDRVENSIDPELAREKFAELRAQYVVTRDTIKAKGRSHATAQEE
ILKLSEVFKQFRLVPKQFDYLVNSMRVMMDRVRTQERLIMKLCVEQCKMP
KKNFITLFTGNETSDTWFNAAIAMNKPWSEKLHDVSEEVHRALQKLQQIE
EETGLTIEQVKDINRRMSIGEAKARRAKKEMVEANLRLVISIAKKYTNRG
LQFLDLIQEGNIGLMKAVDKFEYRRGYKFSTYATWWIRQAITRSIADQAR
TIRIPVHMIETINKLNRISRQMLQEMGREPTPEELAERMLMPEDKIRKVL
KIAKEPISMETPIGDDEDSHLGDFIEDTTLELPLDSATTESLRAATHDVL
AGLTAREAKVLRMRFGIDMNTDYTLEEVGKQFDVTRERIRQIEAKALRKL
RHPSRSEVLRSFLDD
Ligand information
>6xl9 Chain T (length=54) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cgccgcgtcagactcgtaggaatctaaaccctccccttaggggagggtca
aggc
Receptor-Ligand Complex Structure
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PDB6xl9 Structural visualization of transcription activated by a multidrug-sensing MerR family regulator.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		R468 L573 R584 E585 R588
Binding residue
(residue number reindexed from 1)		R320 L425 R436 E437 R440
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005515 protein binding
GO:0016987 sigma factor activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0006352 DNA-templated transcription initiation
GO:0006355 regulation of DNA-templated transcription
GO:0009408 response to heat
GO:0010468 regulation of gene expression
GO:0045892 negative regulation of DNA-templated transcription
GO:2000142 regulation of DNA-templated transcription initiation
Cellular Component
GO:0000345 cytosolic DNA-directed RNA polymerase complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:1903865 sigma factor antagonist complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6xl9, PDBe:6xl9, PDBj:6xl9
PDBsum6xl9
PubMed33976201
UniProtP00579|RPOD_ECOLI RNA polymerase sigma factor RpoD (Gene Name=rpoD)

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