Structure of PDB 6wvv Chain F Binding Site BS02

Receptor Information

>6wvv Chain F (length=497) Species: 5855 (Plasmodium vivax)

ATTVPQVVSLDPTTIPIDYHTPIDDLSIEVKDISAEACPADEGLIVFLLN
SQIKINSSVKDNTINEFMENFTGKLGTSYANDQKKYVSLAYVGCGPANEE
TELEIRKVAYALVTLLHDSHKKVSIIFEIKIEEALFRFFLEHLFYEYVTD
ERFKSATDFIKNLSLHIANADAYKGQIDKARVYFYGTYYAAQLIAAPSNY
CNPVSLSNAAVELAQKVNLECKILDVKELEELKMGAYLSVGKGSMYPNKF
IHLTYKGAQTGKKIALIGKGITFDSGGYNLKAAPGSMIDLMKFDMSGCAA
VLGCAYCIGTIKPDNVEVHFLSAVCENMVSKNSYRPGDIITASNGKTIEV
GNTDAEGRLTLADALVYAEKLGVDYIVDIATLTGAMLYSLGTSYAGVFGN
NDQLINKILSSSKTSNEPVWWLPIINEYRSSLNSKYADLNNISSSVKASS
VVASLFLKEFIENTPWAHIDIAGVSWNFKARKPKGFGVRLLTEFVLN

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 6wvv Chain F Residue 707

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6wvv Active site metals mediate an oligomeric equilibrium in Plasmodium M17 aminopeptidases.
• Resolution: 2.33 Å
• Binding residue (original residue number in PDB): K390 D395 D415 E477
• Binding residue (residue number reindexed from 1): K269 D274 D294 E356
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.4.11.1: leucyl aminopeptidase.
  3.4.13.-

Gene Ontology

Molecular Function

• GO:0030145 manganese ion binding
• GO:0046872 metal ion binding
• GO:0070006 metalloaminopeptidase activity

Biological Process

• GO:0006508 proteolysis
• GO:0019538 protein metabolic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:6wvv, PDBe:6wvv, PDBj:6wvv
• PDBsum: 6wvv
• PubMed: 33303633
• UniProt: A5K3U9|AMPL_PLAVS Leucine aminopeptidase (Gene Name=LAP)