Structure of PDB 6wmu Chain F Binding Site BS02

Receptor Information
>6wmu Chain F (length=471) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IGRTTDPVRMYMREMGTVELLTREGEIDIAKRIEDGINQVQCSVAEYPEA
ITYLLEQYDRVEAEEARLSDLITGFVDDPELAREKFAELRAQYVVTRDTI
KATAQEEILKLSEVFKQFRLVPKQFDYLVNSMRVMMDRVRTQERLIMKLC
VEQCKMPKKNFITLFTGNETSDTWFNAAIAMNKPWSEKLHDVSEEVHRAL
QKLQQIEEETGLTIEQVKDINRRMSIGEAKARRAKKEMVEANLRLVISIA
KKYTNRGLQFLDLIQEGNIGLMKAVDKFEYRRGYKFSTYATWWIRQAITR
SIADQARTIRIPVHMIETINKLNRISRQMLQEMGREPTPEELAERMLMPE
DKIRKVLKIAKEPISMETPIGDDEDSHLGDFIEDTTLELPLDSATTESLR
AATHDVLAGLTAREAKVLRMRFGIDMNTDYTLEEVGKQFDVTRERIRQIE
AKALRKLRHPSRSEVLRSFLD
Ligand information
Receptor-Ligand Complex Structure
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PDB6wmu Structural Basis for Virulence Activation of Francisella tularensis.
Resolution3.18 Å
Binding residue
(original residue number in PDB)		Y394 R397 Q437 R465 T572 L573 E574
Binding residue
(residue number reindexed from 1)		Y253 R256 Q296 R324 T431 L432 E433
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005515 protein binding
GO:0016987 sigma factor activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0006352 DNA-templated transcription initiation
GO:0006355 regulation of DNA-templated transcription
GO:0009408 response to heat
GO:0010468 regulation of gene expression
GO:0045892 negative regulation of DNA-templated transcription
GO:2000142 regulation of DNA-templated transcription initiation
Cellular Component
GO:0000345 cytosolic DNA-directed RNA polymerase complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:1903865 sigma factor antagonist complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6wmu, PDBe:6wmu, PDBj:6wmu
PDBsum6wmu
PubMed33217319
UniProtP00579|RPOD_ECOLI RNA polymerase sigma factor RpoD (Gene Name=rpoD)

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