Structure of PDB 6vvt Chain F Binding Site BS02

Receptor Information
>6vvt Chain F (length=303) Species: 246196 (Mycolicibacterium smegmatis MC2 155) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ADSVRAYLKQIGKVALLNAEEEVELAKRIEAGLYATQKLAELAEKGEKLP
VQQRRDMQWICRDGDRAKNHLLEANLRLVVSLAKRYTGRGMAFLDLIQEG
NLGLIRAVEKFDYTKGYKFSTYATWWIRQAITRAMADQARTIRIPVHMVE
VINKLGRIQRELLQDLGREPTPEELAKEMDITPEKVLEIQQYAREPISLD
QTIGDEGDSQLGDFIEDSEAVVAVDAVSFTLLQDQLQSVLETLSEREAGV
VRLRFGLTDGQPRTLDEIGQVYGVTRERIRQIESKTMSKLRHPSRSQVLR
DYL
Ligand information
Receptor-Ligand Complex Structure
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PDB6vvt The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymerase.
Resolution2.901 Å
Binding residue
(original residue number in PDB)		R290 E312 R319 R416 T426 L427 R438 E439 R442
Binding residue
(residue number reindexed from 1)		R128 E150 R157 R254 T264 L265 R276 E277 R280
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0016987 sigma factor activity
Biological Process
GO:0006352 DNA-templated transcription initiation
GO:0006355 regulation of DNA-templated transcription
GO:0010468 regulation of gene expression
GO:2000142 regulation of DNA-templated transcription initiation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6vvt, PDBe:6vvt, PDBj:6vvt
PDBsum6vvt
PubMed33199626
UniProtA0QW02

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