Structure of PDB 6rmw Chain F Binding Site BS02

Receptor Information
>6rmw Chain F (length=378) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVQWNSRYSYNQLKNKDSLIMFLVEIFRSLFVSNCIDKNIDNVLLSIEEM
FIDHYYNPQHSRLKYLIDDVGIFFTKLPITKAFHTYNKKYRITKRLYAPP
TFNEVRHILNLAQILSLEEGLDLLTFDANETLYPDGHDFNDEVLASYISC
LLKKMNIAIVTAASYNNDAEKYQKRLENLLKYFSKHNIKDGSYKNFYVMG
GESNYLFKCNEEATLYSVPENEWRHYKKFVDYDTVQEILNISEKCLEKVI
KDFGLCAQIQRKEKSIGLVPNKINYMIKYEVLEEAVIRIKKEIIKNKITA
PYCAFNGGQDLWVDVGNKAEGLLILQKLLKIQKKKCCHIGDQFLHSGNDF
PTRFCSLTLWVSNPQETKACLKSIMHLN
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain6rmw Chain F Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6rmw Structure and catalytic regulation of Plasmodium falciparum IMP specific nucleotidase.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		D170 N172 D394
Binding residue
(residue number reindexed from 1)		D127 N129 D341
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.3.99: IMP-specific 5'-nucleotidase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
GO:0050483 IMP 5'-nucleotidase activity
Biological Process
GO:0006190 inosine salvage
GO:0006204 IMP catabolic process
GO:0009117 nucleotide metabolic process
GO:0071590 nicotinamide riboside biosynthetic process
GO:0071592 nicotinic acid riboside biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6rmw, PDBe:6rmw, PDBj:6rmw
PDBsum6rmw
PubMed32591529
UniProtA0A144A134|ISN1_PLAF7 IMP-specific 5'-nucleotidase 1 (Gene Name=ISN1)

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