Structure of PDB 6pb4 Chain F Binding Site BS02

Receptor Information
>6pb4 Chain F (length=483) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RTTDPVRMYMREMGTVELLTREGEIDIAKRIEDGINQVQCSVAEYPEAIT
YLLEQYDRVEAEEARLSDLITGFVDPNAENSIDPELAREKFAELRAQYVV
TRDTIKAKGRSHATAQEEILKLSEVFKQFRLVPKQFDYLVNSMRVMMDRV
RTQERLIMKLCVEQCKMPKKNFITLFTGNETSDTWFNAAIAMNKPWSEKL
HDVSEEVHRALQKLQQIEEETGLTIEQVKDINRRMSIGEAKARRAKKEMV
EANLRLVISIAKKYTNRGLQFLDLIQEGNIGLMKAVDKFEYRRGYKFSTY
ATWWIRQAITRSIADQARTIRIPVHMIETINKLNRISRQMLQEMGREPTP
EELAERMLMPEDKIRKVLKIAKEPISMETPIGDDEDSHLGDFIEDTTLEL
PLDSATTESLRAATHDVLAGLTAREAKVLRMRFGIDMNTDYTLEEVGKQF
DVTRERIRQIEAKALRKLRHPSRSEVLRSFLDD
Ligand information
>6pb4 Chain 2 (length=78) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cgccgcgtcagactcgtaggattatagcataaaaaagatgcgaaaaatgt
gatctagatcacattttaggcaaaaaag
Receptor-Ligand Complex Structure
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PDB6pb4 Visualization of two architectures in class-II CAP-dependent transcription activation
Resolution4.35 Å
Binding residue
(original residue number in PDB)		N396 R397 G398 R436 Q437 R465 R468 K502 I511 D513 D516 L573 E574 R588
Binding residue
(residue number reindexed from 1)		N266 R267 G268 R306 Q307 R335 R338 K372 I381 D383 D386 L443 E444 R458
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005515 protein binding
GO:0016987 sigma factor activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0006352 DNA-templated transcription initiation
GO:0006355 regulation of DNA-templated transcription
GO:0009408 response to heat
GO:0010468 regulation of gene expression
GO:0045892 negative regulation of DNA-templated transcription
GO:2000142 regulation of DNA-templated transcription initiation
Cellular Component
GO:0000345 cytosolic DNA-directed RNA polymerase complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:1903865 sigma factor antagonist complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6pb4, PDBe:6pb4, PDBj:6pb4
PDBsum6pb4
PubMed
UniProtP00579|RPOD_ECOLI RNA polymerase sigma factor RpoD (Gene Name=rpoD)

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