Structure of PDB 6mii Chain F Binding Site BS02

Receptor Information
>6mii Chain F (length=589) Species: 273057 (Saccharolobus solfataricus P2) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QIDYRDVFIEFLTTFKGNNNQNKYIERINELVAYRKKSLIIEFSDVLSFN
ENLAYEIINNTKIILPILEGALYDHILQLDPTYQRDIEKVHVRIVGIPRV
IELRKIRSTDIGKLITIDGILVKVTPVKERIYKATYKHIHPDCMQEFEWP
EDEEMPEVLEMPTICPKCGKPGQFRLIPEKTKLIDWQKAVIQERPEEVPS
GQLPRQLEIILEDDLVDSARPGDRVKVTGILDIKQDSPVKRGSRAVFDIY
MKVSSIEVSSEEDEKKIKDLAKDPWIRDRIISSIAPSIYGHWELKEALAL
ALFGGVPKVLEDTRIRGDIHILIIGDPGTAKSQMLQFISRVAPRAVYTTG
KGSTAAGLTAAVVREKGTGEYYLEAGALVLADGGIAVIDEIDKMRDEDRV
AIHEAMEQQTVSIAKAGIVAKLNARAAVIAAGNPKFGRYISERPVSDNIN
LPPTILSRFDLIFILKDQPGEQDRELANYILDVHSGKSTKNIIDIDTLRK
YIAYARKYVTPKITSEAKNLITDFFVEMRKKSSETPDSPILITPRQLEAL
IRISEAYAKMALKAEVTREDAERAINIMRLFLESVGVDM
Ligand information
Ligand IDADP
InChIInChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
InChIKeyXTWYTFMLZFPYCI-KQYNXXCUSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)OP(=O)(O)O)O)O)N
CACTVS 3.341Nc1ncnc2n(cnc12)[CH]3O[CH](CO[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 10.04O=P(O)(O)OP(=O)(O)OCC3OC(n2cnc1c(ncnc12)N)C(O)C3O
CACTVS 3.341Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO[P@@](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)O)O)O)N
FormulaC10 H15 N5 O10 P2
NameADENOSINE-5'-DIPHOSPHATE
ChEMBLCHEMBL14830
DrugBankDB16833
ZINCZINC000012360703
PDB chain6mii Chain F Residue 2001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6mii DNA translocation mechanism of the MCM complex and implications for replication initiation.
Resolution3.15 Å
Binding residue
(original residue number in PDB)		I303 Y304 P342 G343 T344 A345 K346 S347 Q348 I495
Binding residue
(residue number reindexed from 1)		I288 Y289 P327 G328 T329 A330 K331 S332 Q333 I480
Annotation score5
Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0032508 DNA duplex unwinding

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:6mii, PDBe:6mii, PDBj:6mii
PDBsum6mii
PubMed31308367
UniProtQ9UXG1|MCM_SACS2 Minichromosome maintenance protein MCM (Gene Name=MCM)

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