Structure of PDB 6ldi Chain F Binding Site BS02

Receptor Information
>6ldi Chain F (length=465) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RTTDPVRMYMREMGTVELLTREGEIDIAKRIEDGINQVQCSVAEYPEAIT
YLLEQYDRVEAENSIDPELAREKFAELRAQYVVTRDTIKAKGRSHATAQE
EILKLSEVFKQFRLVPKQFDYLVNSMRVMMDRVRTQERLIMKLCVEQCKM
PKKNFITLFTGNETSDTWFNAAIAMNKPWSEKLHDVSEEVHRALQKLQQI
EEETGLTIEQVKDINRRMSIGEAKARRAKKEMVEANLRLVISIAKKYTNR
GLQFLDLIQEGNIGLMKAVDKFEYRRGYKFSTYATWWIRQAITRSIADQA
RTIRIPVHMIETINKLNRISRQMLQEMGREPTPEELAERMLMPEDKIRKV
LKIAKEPISMETPIGDDEDSHLGDFIEDTTLELPLDSATTESLRAATHDV
LAGLTAREAKVLRMRFGIDMNTDYTLEEVGKQFDVTRERIRQIEAKALRK
LRHPSRSEVLRSFLD
Ligand information
>6ldi Chain 2 (length=50) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcatccgtgagtcgagggtaataaaaccttccagcaaggggaaggtcaag
Receptor-Ligand Complex Structure
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PDB6ldi CueR activates transcription through a DNA distortion mechanism.
Resolution3.69 Å
Binding residue
(original residue number in PDB)		N396 N461 N464 R468 I511 R562 R584 E585 R588
Binding residue
(residue number reindexed from 1)		N249 N314 N317 R321 I364 R415 R437 E438 R441
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005515 protein binding
GO:0016987 sigma factor activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0006352 DNA-templated transcription initiation
GO:0006355 regulation of DNA-templated transcription
GO:0009408 response to heat
GO:0010468 regulation of gene expression
GO:0045892 negative regulation of DNA-templated transcription
GO:2000142 regulation of DNA-templated transcription initiation
Cellular Component
GO:0000345 cytosolic DNA-directed RNA polymerase complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:1903865 sigma factor antagonist complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6ldi, PDBe:6ldi, PDBj:6ldi
PDBsum6ldi
PubMed32989300
UniProtP00579|RPOD_ECOLI RNA polymerase sigma factor RpoD (Gene Name=rpoD)

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