Structure of PDB 6jul Chain F Binding Site BS02

Receptor Information

>6jul Chain F (length=347) Species: 246196 (Mycolicibacterium smegmatis MC2 155)

MTKWVLHVDLDQFLASVELRRRPDLRGQPVIVGGSGDPSEPRKVVTCASY
EAREFGVHAGMPLRAAARRCPDATFLPSDPAAYDEASEQVMGLLRDLGHP
LEVWGWDEAYLGADLPDESDPVEVAERIRTVVAAETGLSCSVGISDNKQR
AKVATGFAKPAGIYVLTEANWMTVMGDRPPDALWGVGPKTTKKLAAMGIT
TVADLAVTDPSVLTTAFGPSTGLWLLLLAKGGGDTEVSSEPWVPRSRSHV
VTFPQDLTERREMDSAVRDLALQTLAEIVEQGRIVTRVAVTVRTSTFYTR
TKIRKLPAPSTDAGQIVDTALAVLDQFELDRPVRLLGVRLELAMDDV

Ligand information

>6jul Chain G (length=11)

ctggggtccta

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6jul A polar filter in DNA polymerases prevents ribonucleotide incorporation.
• Resolution: 2.3 Å
• Binding residue (original residue number in PDB): R42 V44 P62 G218 P219 S220 T221 W242 P244 R245 R247 S248 H249 V250 V251 T252 F297 R334
• Binding residue (residue number reindexed from 1): R42 V44 P62 G218 P219 S220 T221 W242 P244 R245 R247 S248 H249 V250 V251 T252 F297 R334

Enzymatic activity

• Enzyme Commision number: 2.7.7.7: DNA-directed DNA polymerase.

Gene Ontology

Molecular Function

• GO:0000287 magnesium ion binding
• GO:0003677 DNA binding
• GO:0003684 damaged DNA binding
• GO:0003887 DNA-directed DNA polymerase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006260 DNA replication
• GO:0006261 DNA-templated DNA replication
• GO:0006281 DNA repair
• GO:0006974 DNA damage response
• GO:0009432 SOS response
• GO:0042276 error-prone translesion synthesis

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:6jul, PDBe:6jul, PDBj:6jul
• PDBsum: 6jul
• PubMed: 31544946
• UniProt: A0QR77