Structure of PDB 6dcf Chain F Binding Site BS02

Receptor Information
>6dcf Chain F (length=297) Species: 246196 (Mycolicibacterium smegmatis MC2 155) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DSVRAYLKQIGKVALLNAEEEVELAKRIEAGLYATQKLAELAEKGEKLPV
QQRRDMQWICRDGDRAKNHLLEANLRLVVSLAKRYTGRGMAFLDLIQEGN
LGLIRAVEKFDYTKGYKFSTYATWWIRQAITRAMADQARTIRIPVHMVEV
INKLGRIQRELLQDLGREPTPEELAKEMDITPEKVLEIQQYAREPISLDQ
TDSQLGDFIEDSEAVVAVDAVSFTLLQDQLQSVLETLSEREAGVVRLRFG
LTDGQPRTLDEIGQVYGVTRERIRQIESKTMSKLRHPSRSQVLRDYL
Ligand information
Receptor-Ligand Complex Structure
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PDB6dcf Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism.
Resolution3.45 Å
Binding residue
(original residue number in PDB)		E312 R319 R416 T426 L427 R438 E439 R442
Binding residue
(residue number reindexed from 1)		E149 R156 R248 T258 L259 R270 E271 R274
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0016987 sigma factor activity
Biological Process
GO:0006352 DNA-templated transcription initiation
GO:0006355 regulation of DNA-templated transcription
GO:0010468 regulation of gene expression
GO:2000142 regulation of DNA-templated transcription initiation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6dcf, PDBe:6dcf, PDBj:6dcf
PDBsum6dcf
PubMed30297823
UniProtA0QW02

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