Structure of PDB 6bzo Chain F Binding Site BS02

Receptor Information
>6bzo Chain F (length=326) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FVWDEDESEALRQARKDAELTASADSVRAYLKQIGKVALLNAEEEVELAK
RIEAGLYATQLMTELSERGEKLPAAQRRDMMWICRDGDRAKNHLLEANLR
LVVSLAKRYTGRGMAFLDLIQEGNLGLIRAVEKFDYTKGYKFSTYATWWI
RQAITRAMADQARTIRIPVHMVEVINKLGRIQRELLQDLGREPTPEELAK
EMDITPEKVLEIQQYAREPISLDQTIGDEGDSQLGDFIEDSEAVVAVDAV
SFTLLQDQLQSVLDTLSEREAGVVRLRFGLTDGQPRTLDEIGQVYGVTRE
RIRQIESKTMSKLRHPSRSQVLRDYL
Ligand information
Receptor-Ligand Complex Structure
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PDB6bzo Fidaxomicin jamsMycobacterium tuberculosisRNA polymerase motions needed for initiation via RbpA contacts.
Resolution3.38 Å
Binding residue
(original residue number in PDB)		R478 T488 L489 R500 E501 R504
Binding residue
(residue number reindexed from 1)		R277 T287 L288 R299 E300 R303
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005515 protein binding
GO:0016987 sigma factor activity
Biological Process
GO:0006352 DNA-templated transcription initiation
GO:0006355 regulation of DNA-templated transcription
GO:0009415 response to water
GO:0010468 regulation of gene expression
GO:2000142 regulation of DNA-templated transcription initiation
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6bzo, PDBe:6bzo, PDBj:6bzo
PDBsum6bzo
PubMed29480804
UniProtP9WGI1|SIGA_MYCTU RNA polymerase sigma factor SigA (Gene Name=sigA)

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