Structure of PDB 5uha Chain F Binding Site BS02

Receptor Information
>5uha Chain F (length=322) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DESEALRQARKDAELTASADSVRAYLKQIGKVALLNAEEEVELAKRIEAG
LYATQLMTELSERGEKLPAAQRRDMMWICRDGDRAKNHLLEANLRLVVSL
AKRYTGRGMAFLDLIQEGNLGLIRAVEKFDYTKGYKFSTYATWWIRQAIT
RAMADQARTIRIPVHMVEVINKLGRIQRELLQDLGREPTPEELAKEMDIT
PEKVLEIQQYAREPISLDQTIGDEGDSQLGDFIEDSEAVVAVDAVSFTLL
QDQLQSVLDTLSEREAGVVRLRFGLTDGQPRTLDEIGQVYGVTRERIRQI
ESKTMSKLRHPSRSQVLRDYLD
Ligand information
Receptor-Ligand Complex Structure
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PDB5uha Structural Basis of Mycobacterium tuberculosis Transcription and Transcription Inhibition.
Resolution3.906 Å
Binding residue
(original residue number in PDB)		E430 S433
Binding residue
(residue number reindexed from 1)		E224 S227
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005515 protein binding
GO:0016987 sigma factor activity
Biological Process
GO:0006352 DNA-templated transcription initiation
GO:0006355 regulation of DNA-templated transcription
GO:0009415 response to water
GO:0010468 regulation of gene expression
GO:2000142 regulation of DNA-templated transcription initiation
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5uha, PDBe:5uha, PDBj:5uha
PDBsum5uha
PubMed28392175
UniProtP9WGI1|SIGA_MYCTU RNA polymerase sigma factor SigA (Gene Name=sigA)

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