Structure of PDB 5grb Chain F Binding Site BS02

Receptor Information
>5grb Chain F (length=208) Species: 12059 (Enterovirus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KHRIEPVCLIIRGSPGTGKSLATGIIARAIADKYHSSVYSLPPDPDHFDG
YKQQVVTVMDDLCQNPDGKDMSLFCQMVSTVDFIPPMASLAEAGVSFTSK
FVIASTNATNIISDSDAIRRRFYMDCDIEVTDSYKTDLGRLDAGRAAKLC
SENNTANFKRCSPLVCGKAIQLRDRKSKVRYSVDTVVSELIREYSNRSAI
GNTIEALF
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5grb Chain F Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5grb Crystal structure of 2C helicase from enterovirus 71
Resolution2.803 Å
Binding residue
(original residue number in PDB)		C270 S282 C286
Binding residue
(residue number reindexed from 1)		C150 S162 C166
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.28: picornain 3C.
3.4.22.29: picornain 2A.
3.6.1.15: nucleoside-triphosphate phosphatase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0016887 ATP hydrolysis activity

View graph for
Molecular Function
External links
PDB RCSB:5grb, PDBe:5grb, PDBj:5grb
PDBsum5grb
PubMed
UniProtB9VUU3|POLG_HE71 Genome polyprotein

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